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Systemic mycosis

Systemic mycosis. Dimorphs Internal organs Cutaneous Primary Secondary Saprophytes. Systemic mycosis. Tissue staining PAS, H&E, GMS( Gomory Methenamine Silver) Blastomyces dermatitidis Yeast, thick wall, linier Histoplasma capsulatum Yeast, point, blood or bone marrow, wright

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Systemic mycosis

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  1. Systemic mycosis • Dimorphs • Internal organs • Cutaneous • Primary • Secondary • Saprophytes

  2. Systemic mycosis • Tissue staining • PAS, H&E, GMS( Gomory Methenamine Silver) • Blastomyces dermatitidis • Yeast, thick wall, linier • Histoplasma capsulatum • Yeast, point, blood or bone marrow, wright • Paracoccidioides brasiliensis • Multiple budding • Coccidioides immitis • Sphrule

  3. Systemic mycosis • PCR • SABHI • Blood agar • 12 week • Slide culture • Mask, gloves, hood

  4. Blastomycosis • Blastomyces dermatitidis • Canada, South America, Africa • Inhalation of conidia • Chronic disease in lung Disseminated Skin Bone Nose Mouth

  5. Blastomycosis • Culture • SABHI • Round or oval conidia • Unicellular & smooth • Shortly conidiophore • BHI, Blood agar • Yeast • linier bud • Round • Big

  6. Histoplasmosis • Histoplasma capsulatum • America • Bird & bat • Wind • Inhalation • Skin

  7. Histoplasmosis • 90-95% without symptom self limitation • Clinical manifestation • Fever, cough, loose weight, sweat • Lung, spleen, kidney, liver, skin, eye, CNS • Blood culture is positive • Amphotricin-B

  8. Histoplasmosis • Culture • SABHI • Hyphae, macro conidia • BHI, Blood agar • Yeast • Point bud

  9. Coccidioidomycosis • SW America desert • Arthroconidia • Tolerant to dry & salt • 60% without symptoms • 40% mild Bone • Lung blood Skin Brain lymph nod

  10. Coccidioidomycosis • Amphotricin-B • Culture • SABHI • Rectangular arthroconidia • Spherule • Endospore • Blastomyces - C.i • Vaseline germtube + B.d

  11. Paracoccidioidomycosis • South America, Brazil • Saprophyte • Water, soil, plant • Inhalation • Lung • Eating • Mouth & gum disseminated systemic Enlargement of lymph nod

  12. paracoccidioidomycosis • Co trimaxazol • Culture • SABHI • Chlamydioconidia • BHI, Blood agar • Multiple budding • ship's wheel

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