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Meiosis Mistakes

Meiosis Mistakes. Human chromosome abnormalities. Nondisjunction. Failure of homologous chromosomes to separate during cell division. Results. 1 too many OR 1 too few chromosomes. Trisomy: one too many 47 chromosomes Monosomy: one too few 45 chromosomes.

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Meiosis Mistakes

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  1. Meiosis Mistakes Human chromosome abnormalities

  2. Nondisjunction • Failure of homologous chromosomes to separate during cell division

  3. Results 1 too many OR 1 too few chromosomes

  4. Trisomy: • one too many 47 chromosomes • Monosomy: • one too few 45 chromosomes

  5. How can we diagnose these abnormalities? • Karyotypes • Picture of chromosomes in a dividing (div.) cell • Arranged in order by size

  6. Why might this be useful? • Prenatal testing • amniocentesis

  7. Down’s syndrome • Short stature • Round face • Developmental Delays • Eyelids that Cover inner corner Of eyes Trisomy-21

  8. Klinefelter’s syndrome • Affects only males • Sterile • Varying affects Extra X Chromosome

  9. Edward’s syndrome • Growth deficiency • Feeding difficulties • Breathing difficulties • Developmental delays • Underdevelopped organs • Small head • Low-set, malformed ears • Cleft lip/palate • Overlapped, flexed fingers • Trisomy 18

  10. Patau syndrome • heart defects • sloping forehead, • small or missing eyes, • low set ears, • cleft palate • extra fingers and toes • Developmental delays • Trisomy-13

  11. Who determines the sex of the child?

  12. THE FATHER!

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