ENFERMEDAD DE ALZHEIMER

1. ENFERMEDAD DE ALZHEIMER ACTUALIDADES TERAPEUTICAS Dr. Rommel J Carrillo Várguez

2. DEMENCIA: El término... MARCO TULIO CICERON (106-43 a.C) Político, orador, escritor, romano En su ensayo,, “ De Senectute ” “... la pérdida de la memoria era consecuencia de una enfermedad ajena a la senectud...” Cicerón

3. ALOIS ALZHEIMER. El padre... En Noviembre de 1901, se presenta una mujer de 51 años al departamento de psiquiatría de la Universidad Johann Wolfang Goethe en Frankfurt. Cuadro Clínico: deterioro progresivo de memoria, afasia, alucinaciones auditivas, celotipia, paranoia, llanto frecuente e incompetencia psicosocial. AUGUSTE D

4. ALOIS ALZHEIMER. El padre... • Alois Alzheimer, aborda y hace seguimiento por espacio de 2 años. realizando exploraciones clínicas y neuropsicológicas. • 1903 Alzheimer se traslada a Munich. • La paciente es seguida por médicos anónimos. • 8 Abril 1906, fallece Auguste D. Se realiza necropsia cerebral. ALOIS ALZHEIMER Neurofibrillas

5. ALOIS ALZHEIMER. El padre... • El 4 de Noviembre de 1906 durante • “XXXVII Conferencia de Psiquiatras Alemanes”en Tubingen, se presenta el primer reporte anatomo-clínico de la futura enfermedad. • “ Una enfermedad grave caracteristica de la corteza cerebral ” título de la publicación en 1907 Dibujo Original Microscopia Actual

6. ALOIS ALZHEIMER. El padre... • En la cuarta edición de su • TRATADO DE PSIQUIATRIA • KRAEPELIN, hace mención por • primera vez de los casos de Auguste D y otros como la • ENFERMEDAD DE ALZHEIMER

7. ¿Y AHORA QUE?

8. Introduction Introduction Down's syndrome Self-help organisations Background information Introduction Introduction Constipation Research New on our site Interesting links Introduction Conferences on dementia Annual report Introduction Aids Dementia Complex Aggressive behaviour What is it? Agitation and nervousness Provision of Care at home Introduction 2001 EU funding Introduction Disability Forum Introduction Summary Palliative care Introduction Introduction Description Disclosure of the diagnosis Memory Personal hygiene General guidelines Communication Looking after yourself Our opinion on... Involuntary placement Who is affected? Psychotherapy 2000 Our opinion on... Alzheimer projects Country reports Dementia : definition Neurological Associations EURODEM prevalence rates Clinical trials European developments Join our mailing list Dressing Dental problems Care manual Guidelines Clinging and following Suggest an event Full document Mechanical restraint Our full members Suggest a link Huntington's disease Onset of the disease Alcohol Related Dementia Lawnet Manual Dealing with emotions Anger Our aims Memory and Communication Incapable adults Disorientation Physical restraint EP Resolutions Social NGOs Care arrangements Genetic testing 1999 Our latest activities Relevant texts Recommendations Parkinson's disease Our statutes Our associate members Eating and drinking Provision of care at home Binswanger's Disease Anxiety and fear Intranet Is it hereditary? Caring in the later stages Statistics Donations Alzheimer's disease Eyesight Tell us what you think! Embarrassing behaviour Daily life 1998 Apathy Our Board Working groups Personal relationship Care Manual Become full member Failure to recognise people Independent living Fits Children's book Arranging residential care Guidelines on restraint Sponsorship Ask Alzheimer Europe Locking doors Activities of our members Pharmaceutical Industry Other forms of dementia Biomedical research Can it be predicted? Relevant texts Creutzfeldt-Jacob Disease Brusque changes of mood Conference proceedings Tagging Become associate member Hiding/losing objects Hearing Advance directives Financial statements Changes in mood Death and bereavement Lewy-Body Dementia Our staff Diagnosis Younger people with dementia Related disorders Activities and exercise European projects Research Human rights and Biomedicine Children's book AE Networking Treatment Brain tissue donations Legal rights of patients Video surveillance Other news Incontinence Safety Changes in behaviour Having depression Annual reports Multi-Infarct Dementia ERICA Repetitive questioning Medical and physical issues Telephone Helpline Pick's Disease Frustration Jerking movements Sexually behaviour Passive alarms Living alone Main characteristics Rural areas Sleeplessness Hallucinations Moving the person with dementia Three stages Coping with caring Medication as restraint Helping children to cope Early onset dementia Current research Psychological restraint Over-reaction Wandering Loss of manual skills Pressure sores YOUR COMMENTS... De acuerdo las tendencias actuales de prevalencia de (30-50%) en mayores de 85 años: EPIDEMIA

9. ALZHEIMER D. DE PICK CREUTZFEL-JACKOB PRIMARIA DEMENCIA PARKINSON VASCULAR HUNTINGTON Alcohólica SECUNDARIA DETERIORO COGNOSCITIVO: DEPRESION DELIRIUM DISTIROIDISMO PSICOFÁRMACOS DEFICIT NUTRICIONAL PSEUDO DEMENCIA

10. SIGLO XX. • Criterios Diagnósticos • Estudios Epidemiológicos • Prevalencia a nivel mundial

11. FISIOPATOLOGIA:

14. Farmacológico • Inhibidores de Colinesterasa • INHIBIDORES NMDA memantina –AKATINOL- Vitaminas, oxigenadores cerebrales, transfusiones de células de embriones NO SIRVEN

16. SOBRE ESTIMULACION MEMANTINA (AKATINOL) DAÑO NEURONAL

18. Introduction Conferences on dementia Introduction Disclosure of the diagnosis Aggressive behaviour 2001 What is it? Description Constipation Introduction Introduction Interesting links Introduction Aids Dementia Complex Self-help organisations Annual report New on our site Introduction Disability Forum Background information Introduction General guidelines Summary Research Introduction Down's syndrome Memory Agitation and nervousness Palliative care Introduction Introduction Personal hygiene Introduction EU funding Provision of Care at home European developments Dressing Anger Our opinion on... Care manual Looking after yourself Involuntary placement Dental problems 2000 Psychotherapy Our opinion on... Join our mailing list Our full members Lawnet Our aims Guidelines Suggest an event Who is affected? Manual Alcohol Related Dementia Suggest a link Alzheimer projects Neurological Associations Mechanical restraint Country reports Dealing with emotions Communication EURODEM prevalence rates Full document Clinging and following Huntington's disease Dementia : definition Clinical trials Onset of the disease EP Resolutions Provision of care at home Our associate members Social NGOs Recommendations Memory and Communication Tell us what you think! Is it hereditary? Genetic testing Our statutes Donations Physical restraint Alzheimer's disease Binswanger's Disease Relevant texts Eyesight Statistics Caring in the later stages Disorientation Incapable adults Eating and drinking Anxiety and fear 1999 Parkinson's disease Embarrassing behaviour Our latest activities Intranet Care arrangements Working groups Apathy Relevant texts Daily life Independent living Sponsorship Guidelines on restraint Ask Alzheimer Europe Pharmaceutical Industry 1998 Children's book Locking doors Personal relationship Activities of our members Failure to recognise people Biomedical research Arranging residential care Care Manual Become full member Our Board Can it be predicted? Fits Other forms of dementia Creutzfeldt-Jacob Disease Research Younger people with dementia Our staff Financial statements Conference proceedings Brusque changes of mood Hearing Tagging Activities and exercise Children's book Hiding/losing objects Death and bereavement Diagnosis Become associate member Related disorders European projects Human rights and Biomedicine Advance directives Lewy-Body Dementia Changes in mood Repetitive questioning Having depression Brain tissue donations Treatment Incontinence Video surveillance Changes in behaviour AE Networking Annual reports Multi-Infarct Dementia Legal rights of patients ERICA Other news Safety Telephone Helpline Sexually behaviour Pick's Disease Main characteristics Medical and physical issues Passive alarms Living alone Jerking movements Frustration Medication as restraint Coping with caring Helping children to cope Moving the person with dementia Rural areas Sleeplessness Hallucinations Three stages Early onset dementia Loss of manual skills Psychological restraint Wandering Over-reaction Current research YOUR COMMENTS... Pressure sores Otras Opciones Farmacológicas Combinación de aminoácidos de proteína Beta amiloide con otros prótidos (AN 1792) en 1997. 1999 fase clínica 20 pacientes 2002 Fase clínica II suspensión del protocolo por presencia de meningitis aséptica en 15 pacientes ussuarios Dublin, Irlanda THE LANCET Neurology Vol 1 May 2002

20. CONCLUSIONES 1- hay opciones farmacológicas reales 2- RESULTADOS MODESTOS PERO NOTABLES 3- MEJORAN SINTOMATICAMENTE, CONDUCTUALMENTE Y ¿DETIENEN EVOLUCION? 4- LOS PACIENTES DEBEN RECIBIR ESTOS FARMACOS