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MIGRANT STUDIES

MIGRANT STUDIES. Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology. Questions. What is a Migrant Study? How do Migrant Studies differ from Admixture Studies? What is the future for Admixture and Migrant Studies?.

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MIGRANT STUDIES

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  1. MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology

  2. Questions • What is a Migrant Study? • How do Migrant Studies differ from Admixture Studies? • What is the future for Admixture and Migrant Studies?

  3. Migrants pilgrim refugee conquerors displaced people

  4. Migrant Studies Studies taking advantage of migration to one country by those from other countries with different physical and biological environments, cultural background and/or genetic makeup, and different morbidity or mortality experience.

  5. From (KOFF) 1967 PITTSBURGH

  6. Growth of Racial/Ethnic Groups in U.S.A. Percent

  7. The migration of human population provides a tool for the study of the respective roles of host and environmental factors in the development of disease.

  8. Rise and Fall of Migrant Studies

  9. Migratory Patterns Ireland,1817 Germany,1920 Poland, 1900 Jan Dorman

  10. Migration Patterns England, 1979 Trevor Orchard

  11. Migratory Pattern Quebec, 1820 France, 1819 Buffolo,NY Pittsburgh,PA Germany, 1880 Ron LaPorte

  12. 1993 Refugees to U.S. Eastern Europe,1,500 Former Soviet Union 52,000 East Asia 52,000 Africa 7,800 South East Asia 7,000 Latin America 3,500

  13. MIAMI 1950s 1970s HAVANA

  14. Migrant Studies Host Population Source Population Migrant Pop

  15. Incidence of Disease X in source, host, and migrant populations Environmental etiology

  16. Incidence of Disease X in source, host, and migrant populations Genetic etiology

  17. Migrants are almost never representative of their native populations

  18. Existing Migrant Data

  19. Some example of IDDM incidence per 100000 Source Migrant Chinese 7(Shanhai) 3(Hawaia) Japanese 2 (some areas) 3 (Hawaia) Jewish 6 (Israel) 15 (Canada) Mexican 1(Some areas) 10 (Colorado)

  20. Differences in Incidence, Migration vs Geographic Variation

  21. Questions • What is a Migrant Study? • How do Migrant Studies differ from Admixture Studies? • What is the future for Admixture and Migrant Studies?

  22. Admixture studies Hybrid populations H1 Parent population 1 Parent population 2 H2 H3

  23. Incidence of Diseases X in source and hybrid populations

  24. Correlation of Incidence of Disease X and admixture proportion I G H F D Incidence E B C A Admixture proportion

  25. Migration Time Line Showers Culture Genetics 1st Generation Full Assimilation 2nd Generation 3rd Generation Environmental “Shower” Cultural Change Genetic Change Climate Viruses

  26. Migration Time Line 1st Generation 2nd Generation 3rd Generation Environmental “Shower” Cultural Change Genetic Change Beginning Loss of Language Changes in Diet

  27. IDDM in Asian Populations Ten fold Difference

  28. Questions • What is a Migrant Study? • How do Migrant Studies differ from Admixture Studies? • What is the future for Admixture and Migrant Studies?

  29. Heritage Research: The Next Generation of Migrant Studies

  30. Heritage studies Genetic factors Environmental Factors H1 Parent population 1 H2 H3

  31. IDDM Incidence in Latin America Incidence per 100 000

  32. Iberian - heritage collaboration NORTH and SOUTH AMERICA SPAIN

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