1 / 15

Calcinosis Cicumscripta

Calcinosis Cicumscripta. Calcinosis Circumscripta. Uncommon syndrome of ectopic idiopathic, dystrophic, metastatic or iatrogenic mineralization Human beings Circumscripta Universalis Monkeys, dogs, cats, horses, cows, a buffalo, a rabbit and a captive sitatunga. Calcinosis Circumscripta.

paytah
Download Presentation

Calcinosis Cicumscripta

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CalcinosisCicumscripta

  2. CalcinosisCircumscripta • Uncommon syndrome of ectopic idiopathic, dystrophic, metastatic or iatrogenic mineralization • Human beings • Circumscripta • Universalis • Monkeys, dogs, cats, horses, cows, a buffalo, a rabbit and a captive sitatunga

  3. CalcinosisCircumscripta • The pathogenesis not completely understood • calcium salts are deposited in soft tissues in the form of hydroxyapatite or amorphous calcium phosphate • Multiple theories in human orthopedics • repetitive trauma leading to reparative dysfunction • periarticular forces dissecting histiocytic aggregates that initiate osteoclastic activity • hemorrhage from microtrauma causing an exaggerated reparative response. • Classified into four major types according to the type of calcification process and etiology • Dystrophic, metastatic, idiopathic, iatrogenic

  4. Dystrophic • Normal serum calcium and phosphate levels • Calcification localized to a specific area of tissue damage • Primary lesion can be due to injury, necrosis, inflammation or neoplasia • following severe chronic inflammation (reaction to a foreign body, otitisexterna, interdigitalpyoderma, demodicosis, neoplasia , apocrine gland degeneration)

  5. Iatrogenic • Arises secondary to a treatment or surgical procedure • Calcification occurring at the invasive site • can also be classified as dystrophic calcification • medroxyprogestrone and proligestone injections • polidioxanone suture material

  6. Metastatic • Most often form in human beings • Abnormal calcium or phosphate metabolism- hypercalcaemia and/or hyperphosphataemia • chronic renal failure,end stage kidney disease, vitamin D toxicosis. • Few reports in the veterinary literature describe calcinosiscircumscripta in association with renal failure • calcification of foot pads • widespread visceral and vascular mineralization also reported

  7. Idiopathic • Occurs in the absence of known tissue injury or systemic metabolic defect • No causative factor identified • Breed and familial predilection can occur • Can be inherited as an autosomal recessive trait in humans • Hereditary predilection has been suggested in dogs • Several cases of idiopathic paravertebralcalcinosiscircumscripta in dogs and human beings • Especially cervical spine

  8. Small Animals • Dystrophic and idiopathic forms occur more frequently than the metastatic form • Idiopathic seen most commonly in young, large breed dogs • German Shepherds predisposed • Paravertebral cervical • 77 dogs without renal disease • Most common in young dogs • Lesions solitary in 82% of the affected dogs, and occurred most commonly on the hind feet (50%) and tongue (23%) • Multiple other sites including intestinal (1) • Surgical resection curative

  9. Metastatic

  10. Referred to calcinonosiscircumscripta or tumouralcalcinosis Tumouralcalcinosis, a hereditary metabolic dysfunction of phosphate regulation resulting in massive periarticularcalcinosis in humans Horses are rarely lame Horses

  11. Horses • Most commonly lateral aspect of femorotibial joint • sometimes bilaterally • can be closely assoc with joint capsule • Neck, carpus and tarsus • Documented invasion in middle carpal joint and antebrachiocarpal joint. • Thought to be of traumatic origin resulting in dystrophic mineralization • ddxSynovial Osteochondromatosis • Uncommon disorder characterized by the formation of multiple, intra-articular, cartilaginous nodules in the synovial membrane as well as metaplasia of subsynovial connective tissues • these lesions commonly undergo secondary ossification and calcification

  12. References CalcinosisCircumscripta in the Dog: A Retrospective Pathological Study A. K. Tafti, P. Hanna, A. C. Bourque. J. Vet. Med. A(2005) 52: 13–17 Calcinosiscircumscripta in the horse, P. I. Milner Equine vet. Educ. (2009) 21 (11): 589 CalcinosisCircumscripta of the Tongue S. W. Douglas, D. F. Kelly. small anim. Pract. (1966) 7:441 -443. CalcinosisCircumscripta (Calcium Gout) in related Irish Wolfhounds L. N. Owen. small Anim. Pract. (1967) 8: 291-292. Calcinosiscircumscripta following an injection of proligestone in a Burmese cat CR O’Brien, JS Wilkie. Aust Vet J (2001)79:187-189

More Related