220 likes | 813 Views
Vasopressin. Gobind Gill. Structure. http:// upload.wikimedia.org / wikipedia /commons/thumb/c/c6/Arginine_vasopressin3d.png/778px-Arginine_vasopressin3d.png. Structure. http:// www.cancer-therapy.org /CT/v2/B/HTML/32.%20Gomez%20et%20al,%20279-290%20copy.html. Background. Hypothalamus
E N D
Vasopressin Gobind Gill
Structure http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Arginine_vasopressin3d.png/778px-Arginine_vasopressin3d.png
Structure http://www.cancer-therapy.org/CT/v2/B/HTML/32.%20Gomez%20et%20al,%20279-290%20copy.html
Background • Hypothalamus • Pituitary Gland • Stimulii • Functions • Water retention in kidney • Blood vessel constriction
Regulation in Kidney http://vasopressin.files.wordpress.com/2011/09/neg-feedback2.jpg
Regulation in Kidney http://vasopressin.files.wordpress.com/2011/09/neg-feedback3.jpg
Site of Action in Kidney http://faculty.pasadena.edu/dkwon/chapter%2020/Chapter%2020_A_files/slide0056_image007.jpg
Mechanism of Action http://faculty.pasadena.edu/dkwon/chapter%2020/Chapter%2020_A_files/slide0056_image008.jpg
Mechanism of Action http://www.samsca.com/role-vasopressin.aspx
Mechanism of action http://vasopressin.files.wordpress.com/2011/09/vasopressin-receptor.jpg
Vasopressin-Related Disorders • Central diabetes insipidus • Thirst • Dehydration • Large volume of dilute urine • Treatment: desmopressin • Hyponatremia • Low blood osmolarity • Increased water retention • Side effects: headache, nausea vomiting, fatigue, loss of apetite • Treatment: VR2 agonist