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CHAPTER 3 Secondary Glomerulonephritis

CHAPTER 3 Secondary Glomerulonephritis. Rosnawati Yahya Liew Yew Foong. Table 3.1: Causes of secondary glomerulonephritis in adult, 2005-2010. * Hemolytic uraemic syndrome/Thrombotic thrombocytopenic purpura. 4 th MRRB report 2010, Malaysia.

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CHAPTER 3 Secondary Glomerulonephritis

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  1. CHAPTER 3Secondary Glomerulonephritis Rosnawati YahyaLiew Yew Foong

  2. Table 3.1: Causes of secondary glomerulonephritis in adult, 2005-2010 * Hemolytic uraemic syndrome/Thrombotic thrombocytopenic purpura 4th MRRB report 2010, Malaysia

  3. Table 3.2.2.1 (a): Age group at time of biopsy (years), 2005-2010 4th MRRB report 2010, Malaysia

  4. 2005 2006 2007 2008 2009 2010 45 40 35 30 25 Percentage (%) 20 15 10 5 0 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Age group Figure 3.2.2.1: Age group at time of biopsy (years), 2005-2010 4th MRRB report 2010, Malaysia

  5. Figure 3.2.2.2: Gender distribution, 2005-2010 2005 2006 2007 2008 2009 2010 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 Female Male Gender 4th MRRB report 2010, Malaysia

  6. Figure 3.2.2.3: Racial distribution, 2005-2010 2005 2006 2007 2008 2009 2010 80 70 60 50 Percentage (%) 40 30 20 10 0 Malay Chinese Indian Others Race 4th MRRB report 2010, Malaysia

  7. Figure 3.2.3: Clinical presentation by year, 2005-2010 2005 2006 2007 2008 2009 2010 50 45 40 35 30 Percentage(%) 25 20 15 10 5 0 Not Available/ Urine abnormality Nephritic Nephrotic Nephrotic-nephritic Missing Clinical Presentation 4th MRRB report 2010, Malaysia

  8. Figure 3.2.3 (a): Hypertension by year, 2005-2010 Hypertension 60 50 40 Percentage (%) 30 20 10 0 2005 2006 2007 2008 2009 2010 Year 4th MRRB report 2010, Malaysia

  9. Figure 3.2.3 (b) Impaired renal function by year, 2005-2010 eGFR<60ml/min 40 35 30 25 Percentage (%) 20 15 10 5 0 2005 2006 2007 2008 2009 2010 Year 4th MRRB report 2010, Malaysia

  10. Table 3.2.3.1(a): Clinical presentation by age group, 2005-2010 4th MRRB report 2010, Malaysia

  11. Figure 3.2.3.1(a): Clinical presentation by age group, 2005-2010 Urine abnormality Nephritic syndrome Nephrotic syndrome Nephrotic-Nephritic Not available/ Missing 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Age group 4th MRRB report 2010, Malaysia

  12. Figure 3.2.3.1(b) Hypertension by age group 2005-2010 Hypertension 50 45 40 35 30 25 Percentage (%) 20 15 10 5 0 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Year 4th MRRB report 2010, Malaysia

  13. Figure 3.2.3.1(c): Impaired renal function by age group, 2005-2009  eGFR<60ml/min 80 70 60 50 Percentage (%) 40 30 20 10 0 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Age group 4th MRRB report 2010, Malaysia

  14. Figure 3.2.3.2 (a): Clinical presentation by gender, 2005-2010 Urine abnormality Nephritic syndrome Nephrotic syndrome Nephritic-nephritic syndrome Not available/Missing 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 Male Female Gender 4th MRRB report 2010, Malaysia

  15. Figure 3.2.3.2(b): Hypertension by gender, 2005-2010 Hypertension 40 30 Percentage (%) 20 10 0 Male Female Gender 4th MRRB report 2010, Malaysia

  16. Figure 3.2.3.2(c): Impaired renal function by gender, 2005-2010 eGFR<60ml/min 40 30 Percentage (%) 20 10 0 Male Female Gender 4th MRRB report 2010, Malaysia

  17. Table 3.2.3.3 (a): Clinical presentation by histopathology in lupus nephritis, 2005-2010 * 26 cases are missing on lupus subclass 4th MRRB report 2010, Malaysia

  18. Figure 3.2.3.3 (a): Clinical presentation by histopathology in lupus nephritis, 2005-2010 Urine abnormality Nephritic syndrome Nephrotic syndrome Nephrotic–nephritic syndrome Not available/Missing 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 I II III & III+V IV & IV+V V & II+V VI Others Lupus histophatology 4th MRRB report 2010, Malaysia

  19. Figure 3.2.3.3(b) Hypertension by histopathology, 2005-2010 Hypertension 60 50 40 Percentage (%) 30 20 10 0 I II III & III+V IV & IV+V V & II+V VI Others Lupus histopathology 4th MRRB report 2010, Malaysia

  20. Figure 3.2.3.3(c): Impaired renal function by histopathology, 2005-2010 eGFR<60ml/min 80 70 60 50 Percentage (%) 40 30 20 10 0 I II III & III+V IV & IV+V V & II+V VI Others Lupus histopathology 4th MRRB report 2010, Malaysia

  21. Table 3.2.4.1: Renal function by age group in lupus nephritis, 2005-2010 4th MRRB report 2010, Malaysia

  22. Figure 3.2.4.1: Renal function by age group in lupus nephritis, 2005-2010 GFR <15 GFR 15-<30 GFR 30-<60 GFR 60-<90 GFR ≥90 Missing* 100 90 80 70 60 50 Percentage (%) 40 30 20 10 0 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Age Group 4th MRRB report 2010, Malaysia

  23. Figure 3.2.4.2: Renal function at presentation by gender, 2005-2010 <15 15 -< 30 30 -< 60 60 -< 90 ≥90 Missing* 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 Male Female Gender 4th MRRB report 2010, Malaysia

  24. Table 3.2.4.3: Renal function at presentation by histopathology, 2005-2010 *26 cases are missing on lupus subclass 4th MRRB report 2010, Malaysia

  25. Table 3.2.5: Histopathological diagnosis in lupus nephritis by year, 2005-2010 *26 cases are missing on lupus subclass 4th MRRB report 2010, Malaysia

  26. Table 3.2.5.1: Histopathological diagnosis by age group in lupus nephritis, 2005-2010 *26 cases are missing on lupus subclass 4th MRRB report 2010, Malaysia

  27. Table 3.2.5.2: Histopathological diagnosis by gender in lupus nephritis, 2005-2010 *26 cases are missing on lupus subclass 4th MRRB report 2010, Malaysia

  28. Table 3.2.5.3: Histopathological diagnosis by clinical presentation, 2005-2010 *26 cases are missing on lupus subclass 4th MRRB report 2010, Malaysia

  29. Table 3.2.6.1: ARA criteria in lupus nephritis, 2005-2010 4th MRRB report 2010, Malaysia

  30. Figure 3.2.6.2: ARA criteria by age group, 2005-2010 <4 ≥4 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 15- <25 25-<35 35-<45 45-<55 55-<65 >=65 Age group 4th MRRB report 2010, Malaysia

  31. Figure 3.2.6.3: ARA criteria by gender, 2005-2010 <4 ≥4 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 Male Female Gender 4th MRRB report 2010, Malaysia

  32. Figure 3.2.6.4: ARA criteria by histopathology, 2005-2010 <4 ≥4 100 90 80 70 60 Percentage (%) 50 40 30 20 10 0 I II III & III+V IV & IV+V V & II+V VI Others Lupus histopathology 4th MRRB report 2010, Malaysia

  33. Table 3.2.6.5 (a): Extra-renal involvement by gender, 2005-2010 *Patients may have 1 or more “other organ involvements” 4th MRRB report 2010, Malaysia

  34. Figure 3.2.6.5 (a): Extra-renal involvement by gender, 2005-2010 Male Female 60 50 40 Percentage (%) 30 20 10 0 Mucocutaneous Arthritis Serositis Cerebral Haematological Other organ involvement 4th MRRB report 2010, Malaysia

  35. Table 3.2.6.5 (b): Mucocutaneous involvement by gender in lupus nephritis, 2005-2010 *Patients may have 1 or more “other organ involvements” 4th MRRB report 2010, Malaysia

  36. Figure 3.2.6.5 (b): Mucocutaneous involvement by gender in lupus nephritis, 2005-2010 Male Female 90 80 70 60 50 Percentage (%) 40 30 20 10 0 Malar rash Discoid rash Photosensitivity Oral ulcer Mucocutaneous involvements 4th MRRB report 2010, Malaysia

  37. Table 3.2.7.1: Patients Survival estimates for death in lupus nephritis *Missing of 7 censored cases where the outcome date < date of 1st biopsy Event = death; Status as at 31 Dec 2011 or last follow-up 4th MRRB report 2010, Malaysia

  38. Figure 3.2.7.1: Patients Survival estimates for death in lupus nephritis 4th MRRB report 2010, Malaysia

  39. Table 3.2.7.2: Renal Survival estimates for lupus nephritis *Missing of 4 censored and 3 event cases where the outcome date < date of 1st biopsy Event = ESRF; Status as at 31 Dec 2011 or died or last follow-up 4th MRRB report 2010, Malaysia

  40. Figure 3.2.7.2: Renal Survival estimates for lupus nephritis 4th MRRB report 2010, Malaysia

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