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Replicability Project: Cancer Biology

Investigating replicability in cancer biology through systematic sampling of 51 high-impact preclinical papers. All protocols open on OSF. Analyzing data availability and paper reproducibility. Changing research culture towards openness and quality. Implementing Registered Reports for a transparent and rigorous scientific approach.

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Replicability Project: Cancer Biology

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  1. Replicability Project: Cancer Biology Systematic sampling of 51 high-impact preclinical cancer biology papers Completely open preregistration, data, materials: https://osf.io/e81xl/ Registered Reports with eLife Question: For how many papers/experiments could we design a full protocol based on the paper and no input from the original author(s)? 0 of 51 papers (0%) 0 of 197 experiments (0%) Question: For how many papers/experiments was all data available in the paper or a repository? 0 of 51 papers (0%) 3 of 197 experiments (2%)

  2. Counternorms Norms Secrecy Closed Particularlism Evaluate research by reputation Self-interestedness Treat science as a competition Organized dogmatism Invest career promoting one’s own theories, findings Quantity Communality Open sharing Universalism Evaluate research on own merit Disinterestedness Motivated by knowledge and discovery Organized skepticism Consider all new evidence, even against one’s prior work Quality

  3. Anderson, Martinson, & DeVries, 2007

  4. UNIVERSITIES ecosystem PUBLISHERS FUNDERS SOCIETIES

  5. Changing a Research Culture Policy Incentives Make it required Make it rewarding Make it normative Make it easy Make it possible Communities User Interface/Experience Infrastructure

  6. Changing a Research Culture Make it required Make it rewarding Make it normative Make it easy Make it possible TOP Registered Reports

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