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Growth Regulation. Anterior Pituitary. responsible for physical growth growth hormone ( GH ) – levels dictate amount of growth in developing organism peptide hormone. Growth Hormone Regulation. hypothalamus. growth hormone releasing hormone (GHRH). growth hormone inhibiting hormone (GHIH).
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Anterior Pituitary • responsible for physical growth growth hormone (GH)– levels dictate amount of growth in developing organism • peptide hormone
Growth Hormone Regulation hypothalamus growth hormone releasing hormone (GHRH) growth hormone inhibiting hormone (GHIH) anterior pituitary GH half-life is 20 – 30 min growth hormone (GH)
Growth Hormone Effects • cartilage & bone – increased length and width of skeleton • muscle cells – increased cell number (hyperplasia) and cell size (hypertrophy) • ribosome function – increased protein production • fat metabolism – fatty acids as energy source
Growth Hormone Abnormalities • Dwarfism • Gigantism • Acromegaly
Dwarfism Cause: • decreased GH secretion during childhood Result: • limited height (4 feet tall) • normal proportions
Gigantism Cause: • increased GH secretion during childhood Symptom: • height much taller than average Treatment: • surgery if hypersecretion due to tumor growth on pituitary
Acromegaly Cause: • increased GH secretion as an adult Symptom: • bone lengthening has stopped • bone width increases Treatment: • surgery if hypersecretion due to tumor growth on pituitary
