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Female sex hormones: Progesterone

Female sex hormones. OestrogensSynthesis

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Female sex hormones: Progesterone

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    1. Female sex hormones: Progesterone

    2. Female sex hormones Oestrogens Synthesis & secretion Regulation Pharmacological actions Pharmacokinetics Preparations Therapeutic uses Adverse effects Anti-Oestrogens Clomiphene citrate Cyclofenil Tamoxifen citrate Raloxifene Ormeloxifene Progestrogens Synthesis& secretion Regulation Pharmacological actions Pharmacokinetics Preparations Therapeutic uses Adverse effects Anti-progestrogens Mifepristone

    5. http://anatomy.iupui.edu/courses/histo_D502/D502f04/lecture.f04/Female04/cycle.jpg

    7. Progestrogen: Actions

    8. as OCS DUB HRT dysmenorrhea premenstrual syndrome endometriosis threatened abortion post-partum lactation endometrial cancer hypoventilation

    10. Pharmacokinetics Absorption: progesterone undergoes high first pass metabolism. Therefore synthetic preparations are more commonly used. Progesterone esters in oily soln. for i.m. admn. Metabolism: by liver enzymes excretion by urine after conjugation

    11. Antiprogestin

    12. Mifepristone 19-nor-steroid derivative Mechanism: Blocks progest. & glucocorticoid receptors During luteal phase: Pregest. PGs Menstrual bleeding Sensitize myocardium to PGs. HCG production falls ADME: F: 25 %, CYP3A4 metabolism’ t˝: 20 h Uses: Termination of early pregnancy – along with prostaglandin As a cervical ripening agent Post-coital contraceptive Once a month contraceptive Progesterone sensitive tumors Cushing’s syndrome Side effects: Vomiting, diarrhoea, pelvic pain or abdominal pain, about 5% have severe vaginal bleeding

    13. Next Class is on Oral Contraceptive Steroids

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