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Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis

Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis. Matthew B. Dodson* and Anthony G. Moss Auburn University, Cellular & Molecular Biosciences Program Center for Environmental & Cellular Signal Transduction. Mnemiopsis leidyi. 1mm.

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Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis

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  1. Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis Matthew B. Dodson* and Anthony G. MossAuburn University, Cellular & Molecular Biosciences Program Center for Environmental & Cellular Signal Transduction Mnemiopsis leidyi

  2. 1mm . The Mechanism • Wound repair begins within 5 minutes. • Millions of cells migrate to damaged site. • Cells aggregate and pull wound edges together. • Wound heals in 30 minutes without scar.

  3. 100µm Cell Cultures • Wound cells can be cultured. • Form new tissue. • Mimic natural conditions. • Easy to manipulate.

  4. Implications • Model system to study rapid, scar-free wound repair. • Like fetal wound repair. • Molecular genetic tools allow comparison to humans. • Biomedical discovery tool. • Thanks to: • Alabama Commission on Higher Education and the ACHE-GRSP program. • Auburn University Cellular & Molecular Biosciences Program / Center for • Environmental & Cellular Signal Transduction (AU-CMB/CECST). • Alabama EPSCoR and NSF support under Grant No. EPS-0447675 to the CECST • and MCB-0348327 to Dr. A.G. Moss (AU-CMB/CECST, Biological Sciences)

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