who are paa ?

2. who are paa ?

3. who are process analysis & automation ? • was section at British Petroleum • incorporated in 1992 • software supplier of OVERLORD suite • offer systems integration services • independent automation supplier • experienced in multi-vendor platforms • PE/GE/Thermo/Caliper/Tecan/Beckman/Hamilton • Drivers for 75+ manufacturers, 270+ instruments • unique software solutions • Tried and tested, over 400 sold worldwide

4. areas of interest • acoustic emission • sonic spectrometer • quality software, 21CFR • laboratory automation

5. 1998 2004 1986 1988 1995 laboratory automation experience

6. why do we automate ? • speed • reliability • extend instrument operating hours • cost effective analysis • data and sample tracking • User satisfaction

7. why do we automate ?

8. prepare sample prepare sample analyze sample analyze sample report results Laboratory automation - the process collect sample

9. an example • Automated plate reader http://www.paa.co.uk/ftp/labauto/videos/reader_bmg_lo.wmv

10. what automation to offer ?

11. what automation to offer • listen to customer • some what ‘off the shelf’ • some what full flexibility • some want simple • some have no idea what they require • and do you … • sell them what they ask for • sell them what they need

12. what is an integrator ?

13. system what is an integrator ? • instruments are BRICKS • software is the CEMENT • integrator puts it together like a BUILDER hardware software integration

14. what can an integrator offer ? • what happens before the plate is read ? • automation expertise • customer specific user interfaces • what happens after the plate is read • data handling expertise • post run data manipulation • database interaction • installation expertise • highly skilled installation team • installation engineers are programmers as well

15. how do we automate ? • specification • what, where, when, why & how ? • “by next month”, “flexible” • URS, FDS, FAT, SAT • data handling requirements • system throughput • hardware list • integration software

16. 1. specification • User Requirement Specification (URS) • what do you want ? • Functional Design Specification (FDS) • this what we are going to deliver • Factory Acceptance Test (FAT) • check it works before it ships • Site Acceptance Test (SAT) • check it still works after shipping

17. High content plate reader Plate manipulator Peripherals 2. hardware list

18. hardware list – robots

19. automate.it SCARA Mitsubishi PE PlateStak hardware list – robots 2

20. PE PlateStak Thermo RapidStak hardware list – stackers

21. Storage hardware list - storage • Incubator • Storage

22. Liquid Handling Reagent dispensing PlateWash Flexdrop hardware list – liquid handling

23. Barcode reader hardware list – other peripherals Plate reader

24. control & scheduling software

25. control and scheduling software • Two types • STATIC, pre-emptive, time-driven • DYNAMIC, real-time, event-driven

26. STATIC DYNAMIC hit the GO button hit the GO button know exactly what will happen at any time in the process Follow a set process control and scheduling software

27. real-time scheduling OVERLORD Workstation event driven time-resolved scheduling OVERLORD Scheduler time driven Either control software - summary

28. explanation of the difference between scheduler types with our two products what is OVERLORD ?

29. what is Overlord? • suite of automation software by paa • product range is 10 years old • support for more than 270 instruments • two main products • DYNAMIC: Overlord2 • STATIC: OVERLORD Scheduler

30. common features • support for over 270 instruments • data handling facilities • utilizes original instrument software • can integrate with most databases • SQL server, oracle, access • 21 CFR part 11 compliant • full system tracking • error notification • error recovery

31. which product ? Overlord2 • Very Flexible • True Dynamic Scheduling • Takes longer to setup OVERLORD Scheduler • Cannot make decisions • Very easy to use • Obeys critical timings • Schedules fixed processes

32. Overlord2

33. Overlord2 • dynamic/real-time/event • icon based drag and drop set-up • flow chart interface • very flexible • dynamic scheduling • decisions can be made in real-time

34. Overlord2 - Customizable • user GUI & runtime module separable • can use different GUI, Excel could be used • different run engines can be run • processes the flow using Overlord variables • overlord instrument drivers developed quickly • all components can be modified • master or slave • all errors handled with different options • .NET framework, API will be utilized • flexible GUI makes writing assays easier

35. which product ? Overlord2 • Very Flexible • True Dynamic Scheduling • Takes longer to setup OVERLORD Scheduler • Cannot make decisions • Very easy to use • Obeys critical timings • Schedules fixed processes

36. OVERLORD Scheduler

37. OVERLORD Scheduler • static/time driven • icon based drag and drop Gantt chart interface • optimise and interleave different assays e • ach assay run with exact incubation timings • very easy to create an assay • add new assays when the system is running

38. example systems

39. no stacker or laboratory robot • PerkinElmer JANUS system http://www.paa.co.uk/ftp/labauto/videos/elisa_jpm_lo.wmv

40. stacker only • automated TTP Mosquito system http://www.paa.co.uk/ftp/labauto/videos/nano_mosquito_lo.wmv • automated PerkinElmer PlateStak system http://www.paa.co.uk/ftp/labauto/videos/elisa_pe_lo.wmv

41. laboratory robot systems • automated Innovadyne Nanodrop system http://www.paa.co.uk/ftp/labauto/videos/nano_innovadyne_lo.wmv • automated GE Healthcare IN Cell 1000 system http://www.paa.co.uk/ftp/labauto/videos/hcs_1000_lo.wmv

42. factory robot systems • automated dilute & seal system http://www.paa.co.uk/ftp/labauto/videos/mitsubishi_dilute_seal_lo.wmv • automated cell system http://www.paa.co.uk/ftp/labauto/videos/ppw_lo.wmv

43. tracked robot system • BSE workcell http://www.paa.co.uk/ftp/labauto/videos/milk_lo.wmv • DNA workcell http://www.paa.co.uk/ftp/labauto/videos/dna_fss_lo.wmv

44. conclusion laboratory automation has a number of key stages • choice • hardware • software • dynamic scheduler • dynamic scheduler • integration • project management • URS, FDS, FAT & SAT • flexible features make the system what was required not what was asked for