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GLYCOLYSIS

GLYCOLYSIS. REVISITING MITOCHONDRIA. Mitochondria = aerobic respiration Intermembrane space= proton (H + ) pool Mitochondrial matrix = Krebs cycle (Stage 2) Christae (sections of inner membrane that protrude inward) = Electron Transport Chain (Stage 3)

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GLYCOLYSIS

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  1. GLYCOLYSIS

  2. REVISITING MITOCHONDRIA • Mitochondria = aerobic respiration • Intermembrane space= proton (H+) pool • Mitochondrial matrix = Krebs cycle (Stage 2) • Christae (sections of inner membrane that protrude inward) = Electron Transport Chain (Stage 3) • *Glycolysis (Stage 1) occurs in the cytoplasm of cell  anaerobic

  3. Overview of Cellular respiration

  4. Glycolysis What is it? • The first step in cell respiration • Occurs in the cytoplasm of the cell • The production of 2 pyruvate molecules from 1 glucose molecule (through a 10-step series of enzyme-catalyzed reactions) • 2 ATP used; 4 ATP produced

  5. Glycolysis • Substrate-level Phosphorylation(pg. 95) • Using the induced-fit model, enzymes in glycolysis help phosphate groups hook up • The enzyme binds 2 substrates- ADP + Pi • ATP  ADP + Pi • Direction of reaction depends on stage in the cycles This occurs at two of the steps of glycolysis

  6. Glycolysis (pg. 98) 1. Glucose glucose-6-phosphate (G6P) ATP ADP 2. G6P fructose-6-phosphate (F6P) 3. F6P fructose-1,6-biphosphate (F1,6-BP) ATP ADP 4. F1,6-BP dihydroxyacetone phosphate (DHAP) 5. glyceraldehyde-3-phosphate (G3P)

  7. Glycolysis 2 molecules of G3P undergo identical series of reactions: 6. G3P 1,3-bisphosphoglycerate (BPG) Pi NAD+ NADH 7. BPG 3-phosphoglycerate (3PG) ADP ATP 8. 3PG 2-phosphoglycerate (2PG)

  8. Glycolysis 9. 2PG phosphoenolpyruvate (PEP) H2O 10. PEP Pyruvate ADP ATP Glucose + 2 ADP + 2 Pi + 2 NAD+ ----> 2 Pyruvate + 2 ATP + 2 (NADH + H+)

  9. Glucose Song

  10. Glycolysis animation • http://www.northland.cc.mn.us/biology/Biology1111/animations/glycolysis.html

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