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After 7/7 Genomic Implementation at AGI

Learn about the latest advancements in Angus genetic evaluation post-genomic implementation at AGI NBCEC. Discover the benefits of Single-Step genomics, improved models for carcass traits, expanded data sets, and updated genetic correlation estimates. Gain insights into the impact of SNP selection on genomic prediction and explore how Single-Step approach redefines pedigree relationships based on genetic markers. Join the discussion with industry experts to understand the enhanced accuracy and real-time use of genomic information in predicting progeny performance.

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After 7/7 Genomic Implementation at AGI

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  1. After 7/7Genomic Implementation at AGI NBCEC, Brown Bagger, October 4th 2017 Stephen Miller, AGI Genetic Research Director Dan Moser, AGI President and AAA Director of Performance Programs Kelli Retallick, AGI Genetic Services Director

  2. New and Improved Angus Genetic Evaluation Released 7/7/17 "Different isn’t always better, but better is always different." - Author Unknown JULY 2017

  3. Enhancements to Angus Evaluation on 7/7/17 • Single Step genomics • Improved models for carcass traits • Additional genotypes and data • Updated heritability and genetic correlation estimates • Annual update of economic assumptions for $Values

  4. Dan Moser, Ph.D AGI President Stephen Miller, Ph.D AGI Genetic Research Director Kelli Retallick, M.S. AGI Genetic Service Director Lizhen Wang, Ph.D AGI Research Geneticist Lou Ann Adams Director of Information Systems Gayle Billups Programmer Janice Blair Programmer Marg Dressman Software Engineer Jason Kenyon Assistant Director of Information Systems

  5. Yutaka Masuda, Ph.D Shogo Tsruuta, Ph.D Ignacy Misztal, Ph.D Daniela Lourenco, Ph.D RomdhaneRekaya, Ph. D J. Keith Bertrand, Ph.D

  6. Impact of SNP selection on genomic prediction for different reference population sizes Daniela Lourenco I. Menezes, B.O. Fragomeni, H.L. Bradford, S. Tsuruta, I. Misztal ADSA - June, 2017

  7. Data + DNA = Selection Tools that Work • 7.9M birth weights • 8.6M weaning weights • 4.3M post-weaning gain records • 1.5M heifer calving ease scores • 116K carcass records • 1.9M ultrasound records • 21K individual intake records • 257K docility scores • 62K heifer pregnancy observations • 205K mature cow weights • 380K Genotypes

  8. Genotypes in Angus Genetic Evaluation

  9. SS Genetic Trends more stable • Inflating trends with MS • SS and Classic trends very similar

  10. Single Step allows a more COMPLETE model

  11. Carcass Weight EPD

  12. Single Step proves superior in USMARC validation 196 Sires

  13. R-Square – SS predicts AAA performance better

  14. Why Does the Phone Ring? How can two flushmates be this different on EPD? Why don’t genomic scores and EPD match?

  15. Single Step Weights Genomics Variably Across the Population • Multi-step = “One size fits all” • Single Step • Weights genomics more for animals genetically “closer” to the data • Like having an accuracy value for the genomic component of the EPD • Animals distant from data will change less from DNA testing, and have lower EPD accuracy

  16. Range among Full-Sibs has been known for aVERY long time Gregor Mendel 1822-1884 “Mendelian” Sampling

  17. Single-Step Approach • Redefines pedigree relationships among animals based on genetic markers Aguilar et al, 2010

  18. Single-Step Approach • Redefines pedigree relationships among animals based on genetic markers Aguilar et al, 2010

  19. PGS - Semen PGD - Egg Sire

  20. PGS - Semen PGD - Egg Sire

  21. PGS - Semen PGD - Egg Sire

  22. PGS - Semen PGD - Egg Sire

  23. PGS - Semen PGD - Egg Sire Calf1

  24. PGS - Semen PGD - Egg Sire Calf1

  25. PGS - Semen PGD - Egg Sire Calf1

  26. PGS - Semen PGD - Egg Sire Calf1

  27. PGS - Semen PGD - Egg Sire Calf2 Calf1

  28. PGS - Semen PGD - Egg Sire Calf2 Calf1

  29. PGS - Semen PGD - Egg Sire Calf2 Calf1

  30. PGS - Semen PGD - Egg Sire Calf3 Calf2 Calf1

  31. the root of all progress Variation

  32. Variation the root of all progress

  33. Variation in BW EPD – ET progeny • 646 ET from commercial recipients – centered on +2 parental average

  34. I mate a +2 dam to +2 sire and progeny is +5,… really?

  35. Really!

  36. What does theory and Mendel say is possible? More range in “True EPD” possible than observed in EPD • 1,000 simulated progeny

  37. Two ET Full sibs Sib A  BW EPD 1.6 Genomic Score 61 Sib B BW EPD 2.5 Genomic Score 23

  38. Top side of Sire pedigree

  39. Expected Relationship of Schearbrook Shoshone to calf?

  40. 1/2 1/4 1/8 1/16 1/32 Expected Relationship of Schearbrook Shoshone to calf? 1/64

  41. Calf with higher BW EPD is 15% MORE related to the higher BW EPD Ancestors

  42. Calf with higher BW EPD is 13% LESS related to the lower BW EPD Ancestors

  43. Summary of Changes • Narrower ranges for some traits, greater ranges for others • Minimal change for proven animals, considerable change for some young animals • More variation among half- and full-sibs • More current, real-time use of genomic information • More accurate prediction of progeny performance

  44. Questions/Discussion Dan W. Moser, Ph.D. AGI President dmoser@angus.org 816-383-5196 Kelli Retallick, M.S. Genetic Service Director kretallick@angus.org 816-383-5190 Stephen Miller, Ph.D. Genetic Research Director smiller@angus.org 816-383-5157

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