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Buspirone

Buspirone. Ghyasvand , M.D. Roozbeh Hospital, TUMS 2013. Pharmacologic Actions. Full agonist for presynaptic 5-HT1A receptors Partial agonist for postsynaptic 5-HT1A r. Weak antagonist for 5-HT2C r. Agonist& antagonist for D2 r. Pharmacologic Actions ….

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Buspirone

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  1. Buspirone Ghyasvand, M.D. Roozbeh Hospital, TUMS 2013

  2. Pharmacologic Actions Full agonist for presynaptic 5-HT1A receptors Partial agonist for postsynaptic 5-HT1A r. Weak antagonist for 5-HT2C r. Agonist& antagonist for D2 r.

  3. Pharmacologic Actions … Buspirone (buspar): tab 5&10 mg Absorption is delayed by food ingestion. Because of a short half-life (2 to 11 hours), buspirone is dosed three times daily. Buspirone takes 2 to 3 weeks to exert its therapeutic effects.

  4. Therapeutic Indications Buspirone is a narrow-spectrum antianxiety agent, with demonstrated efficacy only in the treatment of generalized anxiety disorder.

  5. Adverse Reactions Buspirone does not cause weight gain, sexual dysfunction, discontinuation symptoms, or significant sleep disturbance. It does not produce sedation or cognitive and psychomotor impairment. The most common adverse effects of buspirone are headache, nausea, dizziness, and, rarely, insomnia.

  6. Adverse Reactions … Buspirone should be used with caution by persons with hepatic and renal impairment. Pregnancy: group B Breast feeding: L3

  7. Dosage Treatment is usually initiated with either 5 mg orally three times daily or 7.5 mg orally twice daily. The dosage can be raised 5 mg every 2 to 4 days to the usual dosage range of 15 to 60 mg a day.

  8. Switching from a Benzodiazepine to Buspirone The two alternatives are as follows: First, the clinician can start buspirone treatment gradually while the benzodiazepine is being withdrawn. Second, the clinician can start buspirone treatment and bring the person up to a therapeutic dosage for 2 to 3 weeks, while the person is still receiving the regular dosage of the benzodiazepine, and then slowly taper the benzodiazepine dosage.

  9. Switching from a Benzodiazepine to Buspirone … Patients who have received benzodiazepines in the past, especially in recent months, may find that buspirone is not as effective as the benzodiazepines in treating their anxiety. This might be explained by the absence of the immediate mildly euphoric and sedative effects of the benzodiazepines. The coadministration of buspirone and benzodiazepines may be effective in the treatment of anxiety disorders that have not responded to treatment with either drug alone.

  10. THANK YOU Any Question?

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