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Vancomycin

Vancomycin. Glycopeptide antibiotic Cynthia Tallent. Introduction. Glycopeptide antibiotic Used to treat gram-positive bacteria Inhibits bacterial cell wall production Resistant strains have been identified. Outline. History Properties Inhibition of Cell Wall Biosynthesis Resistance

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Vancomycin

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  1. Vancomycin Glycopeptide antibiotic Cynthia Tallent

  2. Introduction • Glycopeptide antibiotic • Used to treat gram-positive bacteria • Inhibits bacterial cell wall production • Resistant strains have been identified

  3. Outline • History • Properties • Inhibition of Cell Wall Biosynthesis • Resistance • Analog Research • Review

  4. History • Discovered in 1956 • Originally from Indonesian soil cultures • Structure was elucidated in 1983

  5. Structure

  6. Properties • Administered Intravenously • Administered Orally • pH 3-5 in aqueous solution • P = 2.5

  7. Bacterial Cell Walls • Composed of peptidoglycans • Help to prevent lysis • Gram positive bacteria have thick cell walls

  8. Cell Wall Biosynthesis

  9. Inhibition of Cell Wall Biosynthesis

  10. Vancomycin Resistance • Enterococcus and Staphylococcus aureus • Changes D-Ala-D-Ala to D-Ala-D-Lactate • Bifunctional model • Add Hydrophobic substituents to vancosamine sugar

  11. Adding Hydrophobic substituents to vancosamine sugar Loss of affinity did not lose anti-bacterial effect Disaccharide fragments are effective Christopher Walsh

  12. DCB-PV is effective against Vancomycin Resistant Strains Analogs

  13. Review

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