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Breast cancers with BRCA1 Treatment – neoa djuvant therapy. Cisplatin monotherapy pCR in 34/50 (68%) !!! PR in 15/50 (30%) SD in 1/50 (2%) 10/60 pts on treatment. Breast cancers with BRCA1 Treatment – neoa djuvant therapy. 50 pts 7 - second primary BC treated CHTH
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Breast cancers with BRCA1 Treatment – neoadjuvant therapy • Cisplatin monotherapy • pCRin 34/50(68%) !!! • PR in 15/50(30%) • SD in 1/50 (2%) • 10/60 pts on treatment
Breast cancers with BRCA1 Treatment – neoadjuvant therapy 50 pts 7 - second primary BC treated CHTH in the past 4 - treated CHTH before CISPL SURGERY + CHTH (CMF, AT, FAC, AC) 8 pts – PR 3 pts - pCR
Breast cancers with BRCA1 Treatment – neoadjuvant therapy 39 pts 31/39 = 79,5% pCR CISPLATIN – first option of CHTH!
Breast cancers with BRCA1 Cis-platinum neoadjuvant therapy (first treatment) for sub-groups of tumors T3-4 or T2 N(+) • CPR - 77.3% (17 / 22)