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5-MeTHF

FA. Folate Metabolism. DHF. DHF-Glu. DNA. SAM. Methionine. THF. Gly. THF- Glu n. Sercosine. SAH. B12. dTMP. 5-MeTHF Glu n. 5,10-MeTHF Glu n. DNA Methylation. DNA Synth. dUMP. Homocysteine. 5-MeTHF. Nucleotide Biosynthesis Rxns. Methylation Rxns. CIRCULATION.

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5-MeTHF

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  1. FA Folate Metabolism DHF DHF-Glu DNA SAM Methionine THF Gly THF- Glun Sercosine SAH B12 dTMP 5-MeTHF Glun 5,10-MeTHF Glun DNAMethylation DNA Synth dUMP Homocysteine 5-MeTHF Nucleotide Biosynthesis Rxns MethylationRxns CIRCULATION

  2. Resynthesis of Methionine Methionine Cobalamin 5-methyl THF Methylene THF reductase S-adenosylmethionine Methioninesynthase or Homocysteine methyl -transferase 5,10 methylene THF 5-adenosyl homocysteine Glycine Serine HydroxymethylTransferase Serine Methylcobalamin Homocysteine THF Role of Folate Role of B12 Cystathionine

  3. Association Between Brain Aging and B Vitamins • Hypothesis #1: • Accumulation of phosphorylated brain tau protein phosphate(PP2A) is a characteristic of Alzheimers • How does this relate ? • When Hcy cant metabolize and begins to form more SAH, there is inhibition of methyltransferase-dependent reactions, which results in reduced methylation of PP2A • This inhibits PP2A methyltransferase (PPMT) and results in accumulation of phosphorylated tau

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