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Chapter 62. Birth Control. Birth Control. Interfering with the reproductive process at any step from gametogenesis to nidation (implantation of a fertilized ovum). Safety. Difficult to assess
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Chapter 62 Birth Control
Birth Control • Interfering with the reproductive process at any step from gametogenesis to nidation (implantation of a fertilized ovum)
Safety • Difficult to assess • A large quantity of our data was gathered when birth control was used in higher doses than are used today • Effectiveness vs. safety
Selecting a Birth Control Method • Consider: • Effectiveness • Safety • Personal preference
Oral Contraceptives • Mechanism: inhibit ovulation • Classification (two main categories) • Combination oral contraceptives (OCs) • Estrogen and progestin • Progestin-only OCs • Three major subgroups of combination OCs • Monophasic • Biphasic • Triphasic
Combination Oral Contraceptives (OCs): Adverse Effects • Thromboembolic disorders • Hypertension • Cancer • Teratogenic effects • Abnormal uterine bleeding • Use in pregnancy and lactation • Benign hepatic adenoma • Glucose intolerance • Other adverse effects
Noncontraceptive Benefits of OCs • Decrease risks of ovarian cancer, endometrial cancer, ovarian cysts, pelvic inflammatory disease, benign breast disease, iron deficiency, anemia, and acne • Favorable effect on menstrual cycles • Reduced cramps; lighter, shorter, more predictable flow
Combination Oral Contraceptives—Drug Interactions • Drugs and herbs that reduce the effects of OCs • Rifampin • Ritonavir • Antiepileptic drugs • St. John’s wort
Combination Oral Contraceptives: Drug Interactions • Drugs whose effects are reduced by OCs • Warfarin • Insulin • Oral hypoglycemics • Drugs whose effects are increased by OCs • Several agents, including theophylline, tricyclic antidepressants, diazepam, and chlordiazepoxide • Drugs that elevate potassium should be avoided by patients on yasmin (Yaz)
Combination Contraceptives with Novel Delivery Systems • Transdermal contraceptive patch • Vaginal contraceptive ring
Long-Acting Contraceptives • Subdermal etonorgestrel implants • Depot medroxyprogesterone acetate (MPA) • Intrauterine devices • Spermicides • Barrier devices • Condoms: male and female • Diaphragm • Cervical cap
Drugs for Medical Abortion • Mifepristone (RU 486) with misoprostol • Blocks uterine progesterone receptors • Adverse effects • Bleeding • Cramping • Nausea • Vomiting • Diarrhea • Headache
Drugs for Medical Abortion • Methotrexate with misoprostol • Prostaglandins: misoprostol, carboprost, dinoprostone
Emergency Contraception • Contraception implemented after intercourse • Following rape, failed contraception, or failure to use contraception • Plan B • 2 high-dose tablets of levonorgestrel (progestin) • 1 tablet within 72 hours and another 12 hours later • Alternatives to Plan B