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Toxicology: A History. History of Drugs and the Legislation made to control them. Before we can learn History…. We need to learn drug classifications and categories. Drug categories:. Depressants Stimulants Hallucinogens Date-rape drugs Steroids. Depressants .
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Toxicology: A History History of Drugs and the Legislation made to control them
Before we can learn History… • We need to learn drug classifications and categories
Drug categories: • Depressants • Stimulants • Hallucinogens • Date-rape drugs • Steroids
Depressants • Depressants slow down your central nervous system to make you sleepy and lethargic
Types of Depressants: • Alcohol- the most commonly abused drug • Alcohol is physically addictive with dangerous withdrawal symptoms
Alcohol Blood Levels • As the blood level rises, the toxic effects become more pronounced • 0.03% = giddy emotions • 0.08% = legal limit- coordination, reaction time, and judgment decline • 0.12% = nausea and vomiting • 0.25% = likely to enter coma • 0.30% = Deep Coma • 0.40% = Death
Types of Depressants • Opiates: chemicals derived from the sap of poppies
Opiates • Opiates: • Are Narcotic Sedatives (sleep producing) • Are Analgesics (pain relieving) • Produce: • Euphoria • Lethargy • Coma and Death (in large doses)
Examples of opiates: • Morphine • Codeine • Heroine • Hydrocodone (vicodine) • Oxycodone (oxycotton) • Methadone
Barbiturates • Derived from barbituric acid and used as sleeping pills and anti-seizure medicine • Most common form: phenobarbital
Stimulants • Stimulants increase alertness, lessen fatigue, and suppress appetite. • With continued use, they cause: irritability, anxiousness, aggressive behavior, paranoia, fatigue, and depression
Stimulant side effects: • Tachyphylaxis- the body gets used to the drug and lessens the effect. In order to get high, the user must take more and more
Type of Stimulants • Amphetamines- increases the levels of hormones in the body • Meth (methamphetamines)
Examples of Stimulants: • Xanthine (Xanax) • Caffeine • Nicotine • Meth • Ephedrine/Pseudoephedrine • Adderall • MDA and MDMA • Cocaine
Hallucinogens • Alter perceptions and mood, lead to delusional thinking, and cause hallucinations
Hallucination v. delusion • Hallucination: sensoryexperience that isn’t real and may affect any or all of the senses • Delusion: false beliefs that have little or no basis in reality
Types of Hallucinogens: • Marijuana • Cacti and Mushrooms • Chemicals
Marijuana • Most commonly used and mildest hallucinogen • Derived from the Cannabis sativaplant • Active Ingredient: Tetrahydrocannibinol(THC)
Cacti and Mushrooms • Peyote- small Mexican cactus used in Native American rituals • Mushrooms- possession isn’t illegal, but use is
Chemicals • Made in a laboratory • Common chemicals: • Lysergic Acid Diethylamide(LSD) • Phencyclidine (PCP)
Date-Rape Drugs • Cause: • Sedation • Compliance • Poor Judgment • Memory Loss
Common Date-Rape Drugs • Rohypnol (flunitrazepam) • Ecstasy • GHB • Ketamine
Steroids • Appear natural in small amounts • Cause muscle growth, increased strength, and improved reflexes when taken in large amounts
Negative effects of Steroids • Hair Loss • Impotence • Liver Damage • Aggressive Behavior
Controlled Substances Act • 1970 act- made manufacture, importation, possession, use and distribution of certain substances regulated
Schedule I controlled substance • High potential for abuse • No accepted medical use • Lack of safety for use of the drug
Examples of Schedule I • GHB • Heroin • LSD • Marijuana • Mescaline
Schedule II controlled substance • High potential for abuse • Has a currently accepted medical use • Abuse of drug may lead to dependence
Examples of Schedule II • Cocaine • Opium • Oxycodone • Morphine • Adderall • Vicodin
Schedule III controlled substance • Has potential for abuse less than other drugs in I and II • Currently accepted as medical treatment • Abuse may lead to moderate or low dependence
Examples of Schedule III • Anabolic Steroids • Ketamine • Codeine when mixed with pain killer
Schedule IV controlled substance • Low potential for abuse • Currently accepted as medical treatment • Lead to limited dependence
Examples of Schedule IV • Phenobarbital • Nuvigil (stimulant)
Schedule V controlled substance • Low potential for abuse (lower than any other schedule) • Currently accepted as medical treatment • Very limited dependence
Examples of Schedule V • Cough suppressants with codeine