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Module 1.1: Overview of the Laser Breast Scanner

Module 1.1: Overview of the Laser Breast Scanner. Albert Cerussi Beckman Laser Institute University of California, Irvine. Module Goal. Basic hardware and models used in the Laser Breast Scanner Detail for each step covered in other modules Assumes basic knowledge of diffuse optics.

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Module 1.1: Overview of the Laser Breast Scanner

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  1. Module 1.1:Overview of the Laser Breast Scanner Albert Cerussi Beckman Laser Institute University of California, Irvine

  2. Module Goal • Basic hardware and models used in the Laser Breast Scanner • Detail for each step covered in other modules • Assumes basic knowledge of diffuse optics

  3. Outline • Overview • Diffuse Optical Models • LBS Hardware • LBS Data acquisition

  4. Overview • tissue spectroscopy • uses handheld probe • similar to an ultrasound • Diffuse Optical Spectroscopy

  5. Overview • tissue spectroscopy • uses handheld probe • similar to an ultrasound • Diffuse Optical Spectroscopy

  6. Overview • tissue spectroscopy • uses handheld probe • similar to an ultrasound • Diffuse Optical Spectroscopy

  7. Overview • tissue spectroscopy • uses handheld probe • similar to an ultrasound • Diffuse Optical Spectroscopy

  8. Overview • tissue spectroscopy • uses handheld probe • similar to an ultrasound • Diffuse Optical Spectroscopy

  9. Overview • tissue spectroscopy • uses handheld probe • similar to an ultrasound • Diffuse Optical Spectroscopy ctHHb (deoxy hemoglobin) ctO2Hb (oxy hemoglobin) ctH2O (water) bulk lipids

  10. Overview Y X RIGHT

  11. Frequency-domain Modulated laser diodes Multi-frequency Single distance Discrete (6 ) Absolute optical properties Steady-State Tungsten-Halogen lamp Steady-state Single distance Broadband (650-1000nm) Relative optical spectra LBS Technology/Models • frequency-domain and steady-state spectroscopies

  12. DOS Models: FDPM P1 Approximation to the Transport Equation: Infinite medium Wave vector Optical diffusion Fishkin, J. B., Fantini, S., Vandeven, M. J. and Gratton, E., "Gigahertz photon density waves in a turbid medium: Theory and experiments," Phys. Rev. E, 53, pp. 2307-19, 1996. Cerussi, A. and Tromberg, B., "Photon migration spectroscopy: Frequency domain techniques," in Biomedical photonics handbook, Vo-Dinh, T., Ed., 1st ed.: CRC Press, 2003, pp. 22.1-.17.

  13. DOS Models: FDPM Boundary Condition (semi-infinite) Partial current/Extrapolated Boundary condition Effective source depth Haskell, R. C., Svaasand, L. O., Tsong-Tseh, T., Ti-Chen, F., Mcadams, M. S. and Tromberg, B. J., "Boundary conditions for the diffusion equation in radiative transfer," J. Opt. Soc. Am. A, 11, pp. 2727-41, 1994.

  14. DOS Models: FDPM From the photon density: Photon density amplitude Photon density phase where … Cerussi, A. and Tromberg, B., "Photon migration spectroscopy: Frequency domain techniques," in Biomedical photonics handbook, Vo-Dinh, T., Ed., 1st ed.: CRC Press, 2003, pp. 22.1-.17.

  15. DOS Models: SS Reflectance for n=1.4 flux fluence Kienle, A. and Patterson, M. S., "Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium," J Opt Soc Am A, 14, pp. 246-54, 1997.

  16. SPECTROMETER LAMP HANDPIECE APD LBS Hardware NETWORK ANALYZER S R A BRIDGE RF SWITCH DC SOURCE T T T T T TISSUE T

  17. LBS Hardware Each method calibrated separately • Frequency-domain • unknown source terms (S(), 0()) • phantom of known optical properties • Steady-state • unknown spectral response • ideal reflector with known spectral response

  18. LBS Hardware WARNING! It is essential that these calibrations are performed properly. - data quality compromised - data may be useless

  19. LBS Data Acquisition modulation 50 MHz ~ 1 ms

  20. LBS Data Acquisition modulation 50 MHz ~ 1 ms 201 frequency sweep 100 MHz

  21. LBS Data Acquisition modulation 50 MHz ~ 1 ms 201 frequency sweep 100 MHz 50-500 MHz(~ 200 ms)

  22. LBS Data Acquisition modulation diffusion model

  23. LBS Data Acquisition modulation diffusion model global fit

  24. LBS Data Acquisition modulation diffusion model global fit optical properties

  25. LBS Data Acquisition modulation diffusionmodel absorption &scattering

  26. LBS Data Acquisition modulation diffusionmodel absorption &scattering power law

  27. LBS Data Acquisition modulation diffusionmodel absorption &scattering broadbandreflectance

  28. LBS Data Acquisition modulation diffusionmodel absorption &scattering broadbandreflectance scale w FDPM

  29. LBS Data Acquisition modulation diffusionmodel absorption &scattering broadbandreflectance scale w FDPM

  30. LBS Data Acquisition modulation diffusionmodel absorption &scattering broadbandreflectance

  31. LBS Data Acquisition modulation diffusionmodel absorption &scattering broadbandreflectance chromophore fit

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