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or When a mouse isn’t just a mouse. J. Delton Hanson*, Charles F. Fulhorst, Antonio Utera

Unique Ecological Hosts for Choclo Virus in Panama and Maporal Virus in Venezuela: Evidence They Are Distinct Species. or When a mouse isn’t just a mouse. J. Delton Hanson*, Charles F. Fulhorst, Antonio Utera. Hantaviruses. RNA viruses Small Medium Large (think Goldilocks)

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or When a mouse isn’t just a mouse. J. Delton Hanson*, Charles F. Fulhorst, Antonio Utera

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  1. Unique Ecological Hosts for Choclo Virus in Panama and Maporal Virus in Venezuela: Evidence They Are Distinct Species orWhen a mouse isn’t just a mouse. J. Delton Hanson*, Charles F. Fulhorst, Antonio Utera

  2. Hantaviruses • RNA viruses • Small • Medium • Large (think Goldilocks) • Old World – Hemorrhagic fever w/Renal Syndrome (1950’s)

  3. Hantaviruses • New World – Hantavirus Cardiopulmonary Syndrome (HPS) • Sin Nombre (1993) • Others identified • Not all cause HPS • Not all HPS’s fatal

  4. Hantaviruses • Host - Virus • 1:1 Long-term relationships • Requirement for species recognition

  5. Hantaviruses • Large distribution follows host Peromyscus maniculatus Peromyscus leucopus

  6. Hantaviruses • Large distribution follows host

  7. Hantaviruses • Large distribution follows host

  8. * * * * * 0 500 Kilometers Hantaviruses • Large distribution follows host Rio mamore virus Oligoryzomys microtis Richter, Hanson, Cajimat, Milazzo, and Fulhorst. Geographical range of Rio Mamoré virus (family Bunyaviridae, genus Hantavirus) in association with the small-eared pygmy rice rat (Oligoryzomys microtis). Vector-Borne and Zoonotic Diseases.

  9. Hantaviruses • Closely related viruses w/closely related hosts • Oryzomys sp w/ Bayou and Catacamas viruses

  10. Hantaviruses • Closely related viruses w/closely related hosts • Sigmodon sp w/ Muleshoe and Blackcreek Canal

  11. Hantaviruses Bradley et al. 2008

  12. Hantaviruses Bradley et al. 2008

  13. Hantaviruses • 2000 – Choclo virus – HPS • Panama • Oligoryzomys fulvescens (fulvous pygmy rice rat) • 2004 – Maporal virus – no HPS? • Venezuela • Oligoryzomys fulvescens (fulvous pygmy rice rat) • Violates 1:1 assumption

  14. Oligoryzomys • Small, long tailed • Grass adapted (Reithrodontomys) • Peri-domestic

  15. Oligoryzomys fulvescens

  16. ? Oligoryzomys fulvescens Rogers, D. S., D. K. Hardy, J. D. Hanson, E. A. Arellano, N. Lewis-Rogers and F. X. González-Cózatl. 2009. Molecular phylogenetics of Oligoryzomys fulvescens based on cytochrome b gene sequences, with comments on the evolution of the genus Oligoryzomys. Miranda, GB, Oliveira, LFB, Andrades-Miranda, J, Langguth, A, et al. Phylogenetic and phylogeographic patterns in sigmodontine rodents of the genus Oligoryzomys.

  17. TPMV-VRC 66412-Ind THAIV-Thai749-Tha SEOV-80·39-SKor HTNV-76·118-SKor DOBV-Ano·Poroia-Gre KHAV-MF·43-Rus TOPV-Ls136v-Rus PUUV-Sotkamo-Fin PHV-PH·1-USA TULV-Moravia/5302v/95-CzeR CADV-VHV·574-Ven ANDV-Chile·9717869-Chi LANV-510B-Par RIOMV-HTN·007-Per MAPV-HV·97021050-Ven CHOV-588-Pan BAYV-Hu_La-USA CATV-HV·C1280001-Hon BCCV-USA NYV-RI·1-USA SNV-Convict Creek 107-USA ELMCV-RM·97-USA 0.3

  18. Outgroup O. messorius O. delicatus O. moojeni O. destructor O. longicaudatus O. andinus O. flavescens O. nigripes O. stramineus O. chacoensis O. costaricensis O. vegetus O. fulvescens O. fornesi O. sp1 O. microtis 0.1

  19. Outgroup O. messorius O. delicatus O. moojeni O. destructor O. longicaudatus O. andinus O. flavescens O. nigripes 8.99% 9.73% O. stramineus O. chacoensis O. costaricensis O. vegetus O. fulvescens 11.06% O. fornesi O. sp1 O. microtis 0.1

  20. Outgroup O. messorius O. delicatus O. moojeni O. destructor O. longicaudatus O. andinus O. flavescens O. nigripes O. stramineus O. chacoensis O. costaricensis O. vegetus O. fulvescens O. fornesi O. sp1 O. microtis 0.1 1.99% 1.25% 1.74%

  21. TPMV-VRC 66412-Ind THAIV-Thai749-Tha SEOV-80·39-SKor HTNV-76·118-SKor DOBV-Ano·Poroia-Gre KHAV-MF·43-Rus TOPV-Ls136v-Rus PUUV-Sotkamo-Fin PHV-PH·1-USA TULV-Moravia/5302v/95-CzeR CADV-VHV·574-Ven ANDV-Chile·9717869-Chi LANV-510B-Par RIOMV-HTN·007-Per MAPV-HV·97021050-Ven CHOV-588-Pan BAYV-Hu_La-USA CATV-HV·C1280001-Hon BCCV-USA NYV-RI·1-USA SNV-Convict Creek 107-USA ELMCV-RM·97-USA 0.3

  22. Take Home Conclusionsi.e. why should you care about mice in Central America

  23. Take Home Conclusionsi.e. why should you care about mice in Central America • A mouse is not a mouse

  24. palustris couesi O. species 2 O. species 1

  25. texensis palustris couesi mexicanus O. species 2 O. species 1

  26. Take Home Conclusionsi.e. why should you care about mice in Central America • A virus is not a virus • HPS vs non HPS • Fatal vs un-noticeable

  27. Take Home Conclusionsi.e. why should you care about mice in Central America • You know what they say about assuming…

  28. Take Home Conclusionsi.e. why should you care about mice in Central America Photo by Michael Patrikeev

  29. Take Home Conclusionsi.e. why should you care about mice in Central America Photo by Michael Patrikeev

  30. Take Home Conclusionsi.e. why should you care about mice in Central America Photo by Michael Patrikeev

  31. Take Home Conclusionsi.e. why should you care about mice in Central America • Deposit vouchers!!!

  32. Abilene Christian University Natural History Collections – Tom Lee American Museum of Natural History – Rob Voss, Marcelo Weksler Angelo State University – Loren Ammerman, Robert Dowler Carnegie Museum of Natural History – Sue McLaren Monte L. Bean Life Science Museum – Duke Rogers Museu Nacional Rio de Janerio – Cibele Bonvincino, Jaoa Oliveria Field Museum of Natural History – Bruce Patterson Instituto de Cienceias Naturales University of Kansas Natural History Museum – Bob Timm Museo de Historia Natural La Salle Museo Nacional de Historia Natural – Guillermo D’Elia Museum of Southwestern Biology – Jon Dunnum, Cheryl Parameter Museum of Vertebrate Zoology – James Patton, Chris Conroy Royal Ontario Museum – Mark Engstrom, Burton Lim Texas Tech University – Robert J. Baker, Heath Garner, Kathy MacDonald National Museum of Natural History – Jeremy Jacobs, Michael Carleton Robert Owen, Jane Indorf Acknowledgments

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