depigmentating cosmetic treatment effective against blemishes

2. depigmentating cosmetic treatment effective against blemishes

3. cosmelan Introduction The cosmelan method cosmelan pack composition Treatment cosmelan Results

4. cosmelan Melanogenesis is the combined process of physical, biochemical and morphological skin factors for protecting itself against the action of sun radiations. It consists of melanin production in the melanocyte, this being a cell located at the basal layer of the epidermis, wherein it acts as a photoprotecting barrier. Melanogenesis: origin of skin depigmentation SYNTHESIS OF MELANIN TYROSINE DOPA DOPAQUINONE Oxidation Cyclisation Tyrosinase(Cu) Tyrosinase(Cu) DOPA DOPAQUINONE EUMELANINS PHEOMELANINS

5. cosmelan Once melanin has been synthesised, melanosomes are exported towards keratinocytes. In keratinocytes, melanosome membranes are disrupted and melanin protects cell DNA from ultraviolet radiations. The continuous desquamation and renewal process of skin corneocytes is the natural mechanism of cell renewal and the melanin removal pathway. Melanogenesis: origin of skin depigmentation MELANOCYTES EUMELANINS: Black or brown-coloured biopolymers. They are responsible for the darkest pigmentations. PHEOMELANINS: Reddish or yellowish biopolymers. They are responsible for the lightest pigmentations.

6. cosmelan The North American dermatologist Dr. T. Fitzpatrickestablished a classification of the skin type based on the quantity and type of melanins produced. It is the reference used worldwide. Human skin colour: skin phototypes

7. cosmelan depigmentating cosmetic method effective against skin pigmentations The cosmelan method acts on those cells responsible for skin pigmentation by controlling pigment production at those areas where there is an excess thereof, thereby succeeding in removing or attenuating skin melanicunaesthetic pigmentations. • It has an intensive and integral depigmentating action. • It is highly effective in all kinds of skin pigmentations. • It can be initiated at any time of the year. • It may be applied to any skin phototype. • It has a broad safety margin. The cosmelan method

8. cosmelan depigmentating cosmetic treatment effective against melanic pigmentations cosmelan 1 cosmelan 2 Pack composition degreasing solution hydra vital factor K 1 treatment session + home care treatment

9. cosmelan professional use degreasing solution cosmelan 1 Pack composition Cleansing and degreasing of the skin in order to ensure a better absorption of the depigmentating substances of the treatment. It is applied at the beauty salon. • Mask with depigmentating active substances. Intensive and integral method against melanic pigmentations of any nature. • Recommendations for use: • Let act for the period of time as recommended according to the skin phototype. • Phototypes I and II: 8 hours • Phototypes III and IV: 10 hours • Phototypes V and VI: 12 hours 10 ml bottle. 10 g pot

10. cosmelan cosmelan 2 home care use • Maintenance cream with depigmentating active substances. • It complements the depigmentating process initiated at the doctor‘s office. • Recommendations for use: • Apply maintenance cream cosmelan 2 by using method 3,2,1. • First 15 days: 3 applications. Morning/noon/night • Next 15 days : 2 applications, Morning/night • From the 2nd month on: 1 application. Night • (*) During the first stage of the home care treatment, avoid exposure to heat sources or direct light. Pack composition 30 g pot. hydra vital factor k Cream for daily use that provides the necessary moisturising and nutrition. 50 ml tube.

11. cosmelan Stage prior to cosmelan treatment Make a clinical datasheet (anamnesis) All data of interest will be collected, including personal, habit-related and technical data (type of skin, type of lesions, associated concerns) and disorder-related factors. Make a personalised diagnosis With the aim to adapt the application protocol in accordance with each patient’s need. Fill the informed consent form Sharing with the patient the treatment process while at the same time making him/her commit him/herself to continue with the home care regimen (basic protocol). Photographic record Thereby ensuring that an objective evaluation can be made of the evolution of the result. Monitoring visits It is important to make monitoring visits with a periodicity adapted to the needs of the particular case. Application protocol

12. cosmelan Analyse the skin with Wood‘s light • Wood‘s light is a light beam emitted by a mercury lamp. • Epidermal melasma: it becomes more obvious with light (dark fluorescence). • Dermal melasma: it becomes attenuated/poor fluorescence. • Mixed melasma: some areas become more obvious whereas others do not. • Inapparentmelasma: it vanishes with light (V or VI). Treatment protocol

13. cosmelan cosmelan treatment protocol Stage 1: remove make-up and tone Cleanse and tonewithhydramilkcleanserand hydratonic. Stage 2: degrease Treatment protocol Degrease the skin by applying the exfoliating solution with a gauze, massaging from the forehead, cheeks and central area of the face.

14. cosmelan cosmelan treatment protocol Stage 3: protect Protect with mesolips protector those areas which, due to their sensitivity, should not be contacted with the mask. Treatment protocol Stage 4: treat Applycosmelan 1 mask with a gloved hand or with a spatula, applying a bigger amount onto the affected areas, taking care of the eye contour and the lips and gently spreading on the chin. Let act for the recommended time according to the skin phototype. The exposure time should be from 8 to 12 hours (as per the professional’s judgment). Once the exposure time is over, remove with abundant water.

15. cosmelan cosmelan treatment protocol Stage 5: gradual inhibition Apply cosmelan 2 maintenance cream following method 3-2-1. First 15 days: 3 applications. Morning/noon/night.* Next days: 2 applications Morning/night. From the first month on: 1 application. Night. (*) During the first stage of home care treatment, avoid exposure to heat sources or direct light. Treatment protocol

16. cosmelan cosmelan home care treatment protocol Stage 6: prescribe Apply hydra-vital factor k cream, indicated to return smoothness and elasticity. Treatment protocol Apply moisturising sun protection several times daily depending on the light exposure.

17. cosmelan Oedema / Erythema They may be one of the treatment manifestations. They are transient. It corresponds to the expected progression after conducting this treatment; depending on skin sensitivity, it may last for a few days. Desquamation Skin changes during treatment Depending on skin sensitivity, it may accompany the home care product application; it usually disappears once the moisturising product has been completely absorbed. Burning / Stinging This sensation is attenuated by repeatedly applying products favouring the suitable moisturising. Tightness sensation

18. cosmelan Solar erythema (avoid UV radiation exposure from the previous 15 days). Pregnancy and lactation. Dermatological diseases, persons who are allergic to some formulation ingredient. Treatments with isotretinoin, antibiotics, hydroquinone. Precautions and contraindications Bacterial, viral, mycotic or herpetic infection. It is not advisable to combine it with other chemexfoliation and/or hair removal technique. The time of exposure to the professional mask will be subject to professional‘s judgment depending on the phototype and the skin characteristics and conditions. In order to extend the result over time, it is essential to complete the home care treatment cycle (gradual inhibition).

19. cosmelan Skin renewal and embellishment from the 2nd week of treatment. Attenuation, diminishing or disappearance of melanic pigmentations since one month of treatment. Reduction in small imperfections of the cutaneous relief, such as acne residual scars. Stimulation of capillary circulation and neoangiogenesis. Results Healthy, bright, rejuvenated and generally whitened skin effect.

20. cosmelan Before After Results | Clinical cases

21. cosmelan Before After Results | Clinical cases

22. cosmelan Before After Results | Clinical cases

23. cosmelan Before After Results | Clinical cases

24. cosmelan • Cosmeceutical line with high vegetable stem cell concentrations. • Pack content: • stem Cell serum restructuractive. • stem Cell crystal fiber mask. • stem Cell active growth factor. Coadjuvant products for beauty salon treatment in subsequent sessions

25. cosmelan • Cosmeceutical line with high vitamin C concentrations. • Pack content: • energy C serum. • energy C crystal fiber mask. • energy C intensive cream. Coadjuvant products for beauty salon treatment in subsequent sessions

26. cosmelan melanogeltouch allkinds of skin post_procedure fastskinrepair allkinds of skin post-treatment Post-treatment continuousmaintenance Repairing cream with anti-oedematous and anti-erythematous properties. Depigmentating occasional treatment of melanic pigmentations. hydra-vital face mask dry and dehydrated skins anti-stress facemask allkinds of skin Coadjuvant products for home care treatment post-treatment post-treatment continuousmaintenance continuousmaintenance Hydronutritious and revitalising facial mask. Soothing and repairing mask. It fights against oxidative stress effects proteoglycans ampoules normal and dry skins moisturising sun protection sensitive,combination and oily skins post-treatment post-treatment continuousmaintenance continuousmaintenance Facial sun cream. Very high protection | SPF50+ Nutritional solution. It prevents and combats the appearance of expression wrinkles.

27. cosmelan post-treatment post-treatment continuousmaintenance continuousmaintenance Cosmeceutical line with high vegetable stem cell concentrations. Cosmeceutical line with high vitamin C concentrations. Coadjuvant products for home care treatment post-treatment continuousmaintenance Cosmeceutical line with whitening and improving action formulated with [meso]white complex®.

28. cosmelan 1. Which is cosmelan mechanism of action? It acts in a non-cytotoxic manner, inhibiting both the production and the transfer of melanin pigments. It produces a superficial chemexfoliation, thereby allowing attenuation and/or removal of more or less deep superficial hyperpigmentations. 2. Which sensations does the patient usually experiment along the 8-hour time of exposure tocosmelan 1 mask? The symptoms may vary between individuals; nevertheless, a slight itching or stinging sensation and tightness can be felt. 3. Which changes does the skin usually undergo in the days following application ofcosmelan 1 mask? Although symptoms vary between individuals, there is usually a slight desquamation, together with some itching, stinging and tightness. FAQ’s

29. cosmelan 4. Is it necessary to take any precaution during treatment? Besides being a necessary requirement in order to avoid post-inflammatory hyperpigmentations, the continuous use of a high-filter solar protection is essential when facing light exposure or any nature, since both natural and artificial light can stimulate melanin synthesis. If because of his/her labour activities one is subject to direct light sources, it is necessary to repeat the sun protection application regularly. During the first week post-treatment, it is advisable to avoid the following activities: swimming in pools, sauna, exposure to direct heat sources, outdoor sports. 5. For how long is it recommended to perform the home care treatment? It is recommended to perform the application for at least 4 months, which may be extended up to 9 months depending on the progression of each individual case. FAQ’s

30. cosmelan 6. In which cases is it recommended to complement cosmelan and depigmentating treatment with tmt system no. 7? Once the cosmelan treatment is over, the professional will assess the possibility to complement the depigmentating effect with the tmt system no. 7 treatment for those hyperpigmentations that because of their more deep location will persist. 7. After how long will the result of the treatment be noticed? One month after having been applying cosmelan2 mask, we can appreciate an attenuation of hyperpigmentations and the disappearance of the most superficial ones, besides an evident improvement in the skin, with unification of the tone. 8. During the 4 months of home care treatimentwith cosmelan, can techniques such as biostimulation be used? Once at the single night application stage, the skin can be treated by means of any treatment, provided it is not photodynamica. FAQ’s

31. cosmelan 9. Can cosmelan 2 be used indefinitely after conducting a treatment with cosmelan? In order to prolong the associated benefits of skin embellishment, cosmelan 2 is often indefinitely maintained as antiaging treatment with longer intervals between applications. 10. How can the intake of certain drugs and/or nutritional supplements affect the treatment result? Many drugs have photosensitising effects on the skin; nutritional supplements contain ingredients that may interfere with the melanin synthesis metabolism. The regular intake of both is to be considered when predicting the efficiency of any depigmentating treatment. Therefore, it is essential to gather as much information as possible through the anamnesis. FAQ’s