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Neurobiology of Reward

Neurobiology of Reward. Reward Components. Affective or Emotional Liking Facial expressions Subjective ratings in humans Motivation Wanting or craving Conditioned approach Operant responding Subjective rating or desire in humans Learning Pavlovian CS-based prediction Anticipatory CR

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Neurobiology of Reward

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  1. Neurobiology of Reward

  2. Reward Components • Affective or Emotional • Liking • Facial expressions • Subjective ratings in humans • Motivation • Wanting or craving • Conditioned approach • Operant responding • Subjective rating or desire in humans • Learning • Pavlovian CS-based prediction • Anticipatory CR • Operant-based CS–(response-outcome) associations • Goal directed behavior

  3. Drug Self-Administration

  4. Drug Self-Administration • Self-administration paradigm • Positive contingency between response and injection of drug • DA agonists promote self-administration • DA agonists in brain promote strong self-administration • DA antagonists block self-administration of DA agonists

  5. Electrical Brain Stimulation

  6. Electrical Brain Stimulation

  7. Reward Using EBS • Electrical brain stimulation (EBS) produces approach behaviors • Self-stimulation paradigm • Positive contingency: response leads to EBS • SS depends on electrode location

  8. Reinforcing EBS • Medial forebrain bundle (MFB) • Ventral tegmental area (VTA) • Nucleus accumbens (NA) • Dopamine projection

  9. Experiments on EBS and DA

  10. Reinforcing EBS cont. • MFB stimulation supports strong responding • Adjust intensity, duration, and pulse frequency of EBS and change responding • Reinforcing effects of MFB stimulation • enhanced by DA agonist drugs • blocked by DA antagonist drugs • DA release increased in NA w/ EBS of MFB

  11. Accumbens: Natural Rewards

  12. Accumbens: Natural vs. Drug Rewards Water Cells

  13. Accumbens: Natural vs. Drug Rewards Cocaine Cells

  14. DA Release During Operant Responding for Sucrose Solution

  15. DA Release During Operant Responding for Cocaine

  16. What about the distinction between liking and wanting?

  17. Liking Liking depends on opiates, not dopamine

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