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Sizing up Selenium

Sizing up Selenium. Lydia Harvengt and Jasmine Meyer. The Facts. You need selenium to live But too much selenium, and you get selenosis When you get selenosis , your breath will smell like garlic When your breath smells like garlic, people may think you’re trying to scare away a vampire

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Sizing up Selenium

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  1. Sizing up Selenium Lydia Harvengt and Jasmine Meyer

  2. The Facts • You need selenium to live • But too much selenium, and you get selenosis • When you get selenosis, your breath will smell like garlic • When your breath smells like garlic, people may think you’re trying to scare away a vampire • When people think you are trying to scare away a vampire, they may peg you as a Twilight fan • Don’t be pegged as a Twilight fan • Watch your selenium intake!

  3. What is selenium?

  4. Natural Form • The most common form in selenium supplements

  5. How much do you need? RDA 55mcg/day Upper limit (UL) 400mcg/ day. National Instututes of Health Office of Dietary Supplements. Selenium – Dietary Fact Sheet. http://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/ (accessed March, 2, 2014).

  6. Supplements 20 % Of Americans take a supplement containing Selenium • Selenium deficiency • Treating Crohn’s disease • Reducing the risk of some cancers • Reducing the risk of cardiovascular disease • Reducing the risk of prostate cancer Why? Common in: Men’s Multivitamins

  7. Selenium is Converted to Selenoproteins in the Body • More than 25 selenoproteins are known • Selenoproteins are active in • Reproduction • Thyroid hormone metabolism • DNA synthesis • Protection from damage and infection • Few pathways are understood National Institutes of Health Office of Dietary Supplements. Selenium – Dietary Fact Sheet. http://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/ (accessed March, 2, 2014).

  8. Mechanism of Incorporation

  9. Please use with CAUTION!

  10. WARNING! • Individuals taking medicine for lowering cholesterol, niacin, sedative medications and warfarin should also exercise caution because of potential interference. U.S. Department of Health and Human Services. Toxicity Profile for Selenium. http://www.atsdr.cdc.gov/toxprofiles/tp92.pdf (accessed March 1, 2014),

  11. Characterization • 1H-NMR spectra • Absorption maxima by UV-VIS • Stretching vibrations from IR spectra • HPLC showing the separation of different forms of selenium

  12. 1H-NMR spectra - Methyl Group - Singlet

  13. 1H-NMR spectra

  14. Key: vs: very strong; s: strong; m: medium; w:weak; vw: very weak; br:broad IR Spectra Nitrogen COO- Nitrogen COO- CH3-Se Parameters Bruker IFS 66 FTIR KBr Pellet Technique 4000-400 cm-1 Nitrogen

  15. Absorption Spectra (UV-Vis)

  16. HPLC-ICP-MS (A) selenium Yeast Slurry and (B) Selenolife Yeast Tablet Prepared from the Yeast Slurry. (1) SelenomethionineSe-oxide (2) S-(methylseleno)cysteine, (3) Selenomethionine

  17. So… where do I find selenium? • Jar of Dirt Video?

  18. Natural Processing

  19. Organic Form Production Methionine is transformed to the organic form of Seleniumby replacing a sulfur atom with a selenium atom. When in the organic form, selenium is regularly absorbed by soil and easily digested. Christensen, K. Selenium – the Essential Trace Mineral. http://www.goatbiology.com/selenium.html (Accessed on March 2, 2014).

  20. Supplement Processing Cultured in Sodium Selenite When cultured, the inorganic forms only make up 1% of the product. The rest of the product can be made into supplements. Images From: http://en.angelyeast.com/contents/1309/20169.html http://www.globalsources.com/gsol/I/Food-additive/p/sm/1078107359.htm#1078107359 Baran, E. J.; ZeitschriftfürNaturforschung. B, A. Chem. Sci. 2005, 60, 663-666.

  21. Conclusion • Selenium is necessary • Selenium supplements (generally) are not necessary in America

  22. Questions?

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