The Role of Systematic review and Meta analysis in Scientific research- Pubrica.com

1. META ANALYSIS & SYSTEMATIC REVIEW Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved

2. META ANALYSIS Copyright © 2019 pubrica. All rights reserved Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

3. Copyright © 2019 pubrica. All rights reserved Writing Meta Analysis Pubrica has extensive experience in conducting meta-analysis a quantitative, formal, epidemiological study design used to systematically assess the results of previous research to derive conclusions about that body of research. Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

4. As a general principle, generating, summarizing, and understanding the best available evidence are essential for establishing the benefits and safety of interventions. A well designed and implemented meta-analysis study can be a great benefit to society. Introduction While meta-analysis has the potential to be a powerful tool in evaluating health care treatments and interventions, there are many potential pitfalls and problems that are yet to be resolved. A poorly performed meta-analysis can perpetuate biases from ill- conceived studies or lead to false conclusions. Contd.. Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved

5. This, in turn, can cause consumers and caregivers, who frequently access results of meta-analysis through websites and popular press, to form incorrect conclusions and can result in inappropriate medical decisions. While the idea behind combining studies to improve precision and power is straightforward, the actual implementation of the process is difficult. Those who act or react based on meta-analysis should understand the various biases that could be incorporated into a review. Examples of some potential pitfalls in meta-analysis include publication bias, pipeline bias, and English language bias. In addition, combining studies that are not similar in study design, population, methods of analysis or outcome definitions can lead to biases as well,which may result in spurious conclusions being drawn. Copyright © 2019 pubrica. All rights reserved Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

6. Services Guidelines for Reporting: Moreover, a useful guide to improve reporting of systematic reviews and meta- analysis is the PRISMA (Preferred Reporting Items for Systematic reviews and Meta- analysis) statement that replaced the QUOROM (Quality of Reporting of Meta- analysis) statemen. Detailed Literature Search: We include all relevant studies, because loss of studies can lead to bias in the study. Typically, published papers and abstracts are identified by a computerized literature search of electronic databases that can include PubMed (www.ncbi.nlm.nih.gov./entrez/query.fcgi), ScienceDirect (www.sciencedirect.com), Scirus (www.scirus.com/srsapp ), ISI Web of Knowledge (https://www.isiwebofknowledge.com), Google Scholar (https://scholar.google.com) and CENTRAL (Cochrane Central Register of Controlled Trials, https://www.mrw.interscience.wiley.com/cochrane/ochrane_clcentral_articles_fs.htm). Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved

7. Heterogeneity Heterogeneity is inherent in meta- analysis, not a problem to be solved. Statistical Analysis It includes clinical components (eg, diversity in patient populations or interventions) and statistical components (eg, random differences). Copyright © 2019 pubrica. All rights reserved Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

8. SYSTEMATIC REVIEW Copyright © 2019 pubrica. All rights reserved Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

9. Performing a rigorous systematic review is multi-step process, which includes Identifying a well-defined focused clinically relevant question, Developing a detailed review protocol with strict inclusion and exclusion criteria, Systematic Review Systematic literature search of multiple databases and unpublished data, in consultation with a medical librarian, Meticulous study identification and Systematic data abstraction, by at least two sets of investigators independently, Risk of bias assessment, and Thoughtful quantitative synthesis through meta-analysis where relevant. Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved

10. Formulate the research question Search for studies Selection of studies Data collection Methodology quality assessment Results are analysed and presented Findings are interpreted. General Structure Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved

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