Clinical trial systematic review-meta-analysis- Publication support

1. STREAMLINING SYSTEMATIC REVIEWS: SIMPLIFYING DATA EXTRACTION AND BIAS ASSESSMENT WITH CHARMS AND PROBAST. An Academic presentation by Dr. Nancy Agnes, Head, Technical Operations, Pubrica Group:  www.pubrica.com Email: sales@pubrica.com

2. In research, systematic reviewsare like guiding stars, leading us to evidence-based conclusions. Working with an abundance of data can be challenging, but CHARMS (Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies) and PROBAST (Prediction model Risk of Bias Assessment Tool) can help. Data extraction is like gathering supplies for a journey, while bias assessment is like charting a safe course. CHARMS helps gather data efficiently, like a well-prepared sailor stocking up on provisions. Meanwhile, PROBAST acts as a lookout, helping spot and avoid biases that could throw us off course. These frameworks simplify our tasks, making research smoother.

3. DATA EXTRACTION AND BIAS ASSESSMENT IN RESEARCH: THE ROLE OF TOOLS LIKE CHARMS AND PROBAST In the systematic review process, data extraction means collecting important information from different studies and organizing it neatly. This can take a lot of time, and mistakes can happen, especially when there are many studies to go through. Researchers often need help gathering data in the same way across different reviewers and making sure it’s accurate and complete. Bias assessmentis about checking if there are any factors in the studies that could make the results less reliable. This step is important to determine whether the evidence is trustworthy. It takes work because it involves understanding research methods and statistics. To make these tasks easier, researchers have created tools like CHARMS and PROBAST. CHARMS helps collect data from prediction modeling studies in a standard way, and PROBAST helps check if prediction models have biases. These tools provide clear steps to follow, which saves time and ensures the review is done well. They help researchers be consistent and reduce mistakes.

4. HOW CHARMS SIMPLIFIES THE PROCESS AND IMPROVES CONSISTENCY CHARMS provides a structured approach to data extraction, ensuring that all relevant information is captured consistently. It helps researchers collect data from prediction modeling studiesin a constructed way. It has a checklist that guides reviewers on what information to gather. This checklist ensures that everything important is noticed, making the results more trustworthy. One great thing about CHARMS is that it makes sure all reviewers follow the same standards. This reduces differences between reviewers, which is important in systematic reviews where many people are involved. CHARMS is also flexible and can be used for different types of studies. It’s not limited to one field, so it’s useful for various research questions. CHARMS helps with data extraction and estimates bias in studies. It includes a feature to detect bias, which enhances transparency and accountability in the review process.

5. HOW PROBAST STREAMLINES BIAS ASSESSMENT AND ENHANCES VALIDITY. PROBAST helps researchers check for bias in prediction model studies. It looks at four areas: who was chosen for the study, the factors being predicted, the outcomes measured, and how the analysis was done. By systematically examining these areas, researchers can spot biases that affect the prediction model’s credibility. One great thing about PROBAST is that it guides researchers through the evaluation process. It provides clear questions for each area, making sure everything important is noticed. Using PROBAST helps researchers check for bias thoroughly, making their reviews more reliable. It makes sure biases aren’t overlooked, which makes the findings more reliable for making decisions based on evidence.

6. STEP-BY-STEP GUIDE ON IMPLEMENTING CHARMS AND PROBAST IN SYSTEMATIC REVIEWS 1.Get to Know CHARMS: CHARMS is a helpful tool for critical appraisal and data extraction in prediction modeling studies. It comprises a checklist for systematic reviews that ensures the accurate collection of essential information. 2.Learn about PROBAST: PROBAST evaluates prediction model study bias using signaling questions. Familiarize yourself with its domains to assess study quality effectively. 3.Customize CHARMS and PROBAST: Adapt these tools to match your review’s objectives and questions. Make sure to cover all relevant aspects and biases specific to your study. 4.Create a Data Extraction Form: Develop a structured form based on CHARMS elements to extract data consistently from all included studies. Include study details, bias domains, and other relevant info. 5.Train Your Reviewers: Training on CHARMS and PROBAST is necessary for consistent and accurate reviews. 6.Use CHARMS for Extraction: Gather data from each study using your customized data extraction form. This method guarantees the capture of all the essential information. 7.Employ PROBAST for Bias Assessment: Use PROBAST to assess bias in prediction models. Evaluate each domain and potential biases with it signaling questions. 8.Document Your Findings: Record your data extraction and bias assessment findings using CHARMS and PROBAST. This documentation will be essential for your review process and any future updates.

7. In conclusion, integrating CHARMS and PROBAST into systematic reviews offers a powerful solution for researchers seeking efficiency and accuracy. CHARMS ensures consistent data extraction, while PROBAST facilitates thorough bias assessment, streamlining the review process. By simplifying these critical tasks, researchers can enhance the reliability and transparency of their findings, ultimately advancing evidence-based decision-making in various fields. With their structured approaches and comprehensive frameworks, CHARMS and PROBAST stand as invaluable tools in the pursuit of robust systematic reviews. Get reliable systematic review services from Pubrica! Our experts will gather and analyze research thoroughly, giving you insightful reviews you can trust. Let’s simplify your review process – reach out to us today!

8. REFERENCE 1.Fernandez-Felix, B. M., López-Alcalde, J., Roqué, M., Muriel, A., & Zamora, J. (2023). CHARMS and PROBAST at your fingertips: a template for data extraction and risk of bias assessment in systematic reviews of predictive models. BMC Medical Research Methodology, 23(1), 1-8. 2.Kuo, R. Y., Harrison, C., Curran, T. A., Jones, B., Freethy, A., Cussons, D., … & Furniss, D. (2022). Artificial intelligence in fracture detection: a systematic review and meta-analysis. Radiology, 304(1), 50-62. 3.Kraft, S. A., McMullen, C., Lindberg, N. M., Bui, D., Shipman, K., Anderson, K., … & Lee, S. S. J. (2020). Integrating stakeholder feedback in translational genomics research: an ethnographic analysis of a study protocol’s evolution. Genetics in Medicine, 22(6), 1094-1101

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