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VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014. Biomarkers nell’asma bronchiale. Guglielmo Scala Napoli. Pathogenesis of Asthma Holgate S, Clin Exp Allergy , 2008. Pathogenesis of Asthma Holgate S, Clin Exp Allergy , 2008.
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VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli
PathogenesisofAsthma Holgate S, ClinExpAllergy, 2008
PathogenesisofAsthma Holgate S, ClinExpAllergy, 2008 La cellula Th2 è fondamentale per la maturazione dell’eosinofilo
PathogenesisofAsthma Holgate S, ClinExpAllergy, 2008
A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science
A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science
PathogenesisofAsthma Holgate S, ClinExpAllergy, 2008 Nasce il concetto di EMTU
Lamina basale è prodotta dalle cell epiteliali Lamina reticolare (MBR) è prodotta dai fibroblasti
A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment P. Holt & P. Sly, Nature Medicine, 2012
Holt & Sly, NatMed 2012 Smascherata la marcia atopica??
The basicsofepithelial-mesenchymaltransition Kalluri R, Weinbergjj R , J ClinInvest. 2009.
The basicsofepithelial-mesenchymaltransition Kalluri R, Weinbergjj R , J ClinInvest. 2009.
A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Khayyal MT 2003, FundamClinPharmacol 22 pazienti : placebo 24 pazienti : propoli
Brazilian Green Propolis: Anti-Inflammatory Property by an ImmunomodulatoryActivity Machado JL et al, 2012, Evidence-Based ComplAltern Med
Caffeic acid phenethyl ester inhibits nuclear factor-kB and protein kinaseB signalling pathways and induces caspase-3 expression in primary human CD4+ T cells Wang et al, 2009, Clin Exp Immunol Theinhibitory effect of CAPE results in the inhibition of cytokine production and proliferation in primary human CD4+ T cells
Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human PolymorphonuclearLeukocytes. Boudreau L, 2012, PlosOne
Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human PolymorphonuclearLeukocytes. Boudreau L, 2012, PlosOne
Propolisinhibits TGF-β1-inducedepithelial-mesenchymaltransition in humanalveolarepithelialcells via PPARγ activation. Kao HF, et al. 2013, IntImmunopharmacol TGF-b Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare
Propolisinhibits TGF-β1-inducedepithelial-mesenchymaltransition in humanalveolarepithelialcells via PPARγ activation. Kao HF, et al. 2013, IntImmunopharmacol TGF-b Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI Se pretrattiamo con CAPE (ac. Caffeico) l’effetto è di minore intensità.
Propolisinhibits TGF-β1-inducedepithelial-mesenchymaltransition in humanalveolarepithelialcells via PPARγ activation. Kao HF, et al. 2013, IntImmunopharmacol The results of this study suggest that natural propolis extracts may prevent TGF-β1-induced EMT in alveolar cells, which may be clinically applied in the prevention and/or treatment of EMT-related fibrotic diseases as well as airway remodeling in chronic asthma