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GRANTS 101:

GRANTS 101:. Everything you want to know about the NIH grants process but are afraid to ask. David Armstrong, Ph.D. Chief, Scientific Review Branch, NIMH. Take-Home Message. Communicate with NIH staff with investigators with institutional administrators http://www.nih.gov.

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GRANTS 101:

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  1. GRANTS 101: Everything you want to know about the NIH grants process but are afraid to ask David Armstrong, Ph.D. Chief, Scientific Review Branch, NIMH

  2. Take-Home Message Communicate • with NIH staff • with investigators • with institutional administrators http://www.nih.gov

  3. National Institutes of Health • Much of the biomedical research in the United States is supported by the Federal Government, primarily the National Institutes of Health (NIH)

  4. FY 2005 Funding By Mechanism (dollars in billions) Total budget $28.8 billion 16% supports 6,000 NIH scientists Spending at NIH $4.7 Spending Outside NIH $24.1 84% supports 212,000 scientists At over 3,000 Universities And Institutes

  5. Finding Your Way at NIH • Comprised of 27 Institutes and Centers • Similar in some ways, but not all • Each has its own mission, budget, activities, priorities, and ways of doing things.

  6. A Typical Institute/Center Office of the IC Director Board of Scientific Counselors National Advisory Council Extramural Intramural Laboratory Studies Clinical Studies Review Grants Program Manage- ment

  7. What is the Mission of NIMH? NIMH’s Mission is to reduce the burden of mental illness and behavioral disorders through research on mind, brain behavior. • Through the support and conduct of research on mental disorders and the underlying basic science of brain and behavior • Ensuring rapid and effective dissemination and use of research results to improve prevention, intervention, treatment, and policy

  8. Multidisciplinary Research at NIMH is Supported Psychologists Psychiatrists Neuroscientists Epidemiologists Physician Scientists Anthropologists Social Workers Sociologists Nurses Nutritionists Neurologists and more!

  9. How do we set priorities? • Relevance – what do we need? • Traction – where are the opportunities? • Innovation – what is new? Relevance +Traction + Innovation = IMPACT

  10. Overall Peer Review Process

  11. What, Who, When • What is the application process? • Who is the right person to contact? • When should I contact someone?

  12. Dual Review System for Grant Applications First level of review Scientific Review Group - Provides initial scientific merit review of grant applications - Rates applications and makes recommendations concerning level of support and duration of award Second level of review Council - Makes recommendations to IC staff concerning funding - Evaluates program priorities and relevance - Advises on policy

  13. The NIH Grant Process WOW! What a great idea Investigator initiated research is core to the NIH grant process

  14. Preparation of the Application • Who at your home institution can help you • Other investigators • Institutional Officials/Administrators • Who at NIH can help you • Project Officer/Program Chief • Scientific Review Administrator (SRA) • Grants Management Specialist/Officer

  15. Who/What is a Project Officer/Program Chief? • Project Officer/Program Chief • is a scientist and administrator • manages grants, contracts, cooperative agreements • identifies needs in scientific areas • identifies scientific areas of special interest and communicates interest • monitors scientific progress and reports program accomplishments • advocates for the best science

  16. Who/What is a Scientific Review Administrator? • Scientific Review Administrator • is a scientist and administrator • manages the review of grants, contracts, cooperative agreements • appoints members to initial review groups/study sections/special emphasis panels • responds to questions about review at Advisory Councils and Board meetings • prepares summary statements reflecting IRG recommendations • if Referral Officer, refers applications to study section for review and to Institute for acceptance into program

  17. The NIH Grant Process (cont) SF424 Writing a grant application can be very time consuming January/February June/July October/November

  18. Preparation of the Application • Help from other investigators • Discuss ideas, critique application • Discuss their experience w/ the NIH application process • Help from Institutional Officials/Administrators • Register for eRA Commons for electronic submission • Prepare budget • Identify sources of funding in addition to NIH • Identify electronic sources of information

  19. Preparation of the Application • Help from NIH Project Officer/Program Chief • Discuss science/proposed project • Discuss NIH Institute’s degree of interest in proposed project • Discuss application and review process • Discuss funding mechanisms

  20. Preparation of the Application Key Questions for Prospective Investigator 1. What do you intend to do? 2. Why is the work important? 3. What has already been done? 4. How are you going to do the work?

  21. Preparation of the Application • Develop your idea • Survey the literature • Contact Investigators working on topic • Prepare a brief concept paper • Discuss with colleagues/mentors • Prepare to do the project • Develop preliminary data • Present to colleagues/mentors/students

  22. Preparation of the Application • What makes a successful application? • Significance (Does the study address an important problem?) • Approach (conceptual framework, design, methods, analyses, problems and alternatives) • Innovation (Is the project original and innovative?) • Investigators (training, suitability for project) • Environment (unique features, collaborations, institutional support)

  23. The NIH Grant Process (cont) Submission Website at: http://era.nih.gov/ElectronicReceipt Soon all grant applications will be received electronically Center for Scientific Review receiving center

  24. The Future: Electronic Research Administration (eRA) • NIH’s vision for the 21st century. • Infrastructure for conducting interactive electronic transactions for the receipt, review, monitoring, and administration of NIH grant awards. • Integrates the external system, NIH eRA Commons and the internal system, IMPAC II. https://commons.era.nih.gov/commons/index.jsp

  25. What is Grants.gov? • The Federal government’s single, online portal for any person, business, or State, Local and Tribal government to electronically: • Find Grant Opportunities • Apply for Grants • A cross-agency initiative involving • 900 grant programs • 26 grant-making agencies • Over $350 billion in annual awards

  26. Why transition? It’s the law… • Public Law (PL) 106-107 Federal Financial Assistance Management Improvement Act of 1999 • Improve the effectiveness and performance of Federal financial assistance programs • Simplify Federal financial assistance application and reporting requirements • Improve the delivery of services to the public

  27. Preparing for Submission –Registration Grants.gov • Applicant institutions must complete one time only registration • Good for electronic submission to all Federal agencies • Detailed instructions at: http://grants.gov/GetStarted • Grants.gov registration requires institutions to: • Obtain a Data Universal Numbering System (DUNS) number • Register in Central Contractor Registry (CCR) • Registration not required to find funding opportunity or download application package, only to submit completed application

  28. Preparing for Submission –Registration (cont) • eRA Commons • PI’s must work through their institutions to register • Applicant institutions must complete one-time only registration • PI’s currently registered only for IAR must work through their institutions for full Commons registration It is critical for institutions to begin this registration process at least 4 weeks before applications are due!

  29. The NIH Grant Process (cont) Individual Research Grant Serial number Amended 1 R01 MH 123456 01 A1 Institute Grant Support Year New Application CSR’s x-ray security facility

  30. The NIH Grant Process (cont) Just ten more reviewers to recruit and the roster is complete. Just 5 more reviewers to recruit Scientific Review Administrator Reviewer

  31. Criteria for Selection of Peer Reviewers • Demonstrated Scientific Expertise • Doctoral Degree or Equivalent • Mature Judgment • Work Effectively in a Group Context • Breadth of Perspective • Impartiality • Interest in Serving • Adequate Representation of Women and Minority Scientists

  32. The NIH Grant Process (cont) Finished! This is hard work. Critique IAR

  33. The NIH Grant Process (cont) First level of review Score (100-500) Human subject concerns Inclusion criteria Vertebrate animal concerns Budget

  34. Confidentiality • Review materials and proceedings of review meetings represent privileged information to be used only by consultants and NIH staff. • At the conclusion of each meeting, consultants will be asked to destroy or return all review-related material. • Consultants should not discuss review proceedings with anyone except the SRA. • Questions concerning review proceedings should be referred to the SRA.

  35. The NIH Grant Process (cont) eRA Summary statement Scientific Review Administrator

  36. Summary Statement • Overall resume and summary of discussion • Essentially unedited critiques • Priority score and percentile ranking • Budget recommendations • Administrative Notes • Animal/Human Subjects Concerns • Concerns about Gender, Minority, Child Inclusion

  37. The NIH Grant Process (cont) Wow a 166 – Will I get paid? Second level of review National Advisory Mental Health Council

  38. Yippee!! Now I only have to worry about getting tenure.

  39. When Preparing an Application • Never assume that reviewers “will know what you mean” • Refer to literature thoroughly • State rationale of proposed investigation • Read instructions • Include well-designed tables and figures • Present an organized, lucid write-up • Obtain pre-review from faculty at your institution

  40. Common Problems in Applications • Lack of new or original ideas • Absence of an acceptable scientific rationale • Lack of experience in the essential methodology • Questionable reasoning in experimental approach • Uncritical approach • Diffuse, superficial, or unfocused research plan • Lack of sufficient experimental detail • Lack of knowledge of published relevant work • Unrealistically large amount of work • Uncertainty concerning future directions

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