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Overview of Alzheimer’s Disease and Other Dementias

Overview of Alzheimer’s Disease and Other Dementias. Colloquium The Aging Population, Alzheimer’s and Other Dementias: Law & Public Policy University of Iowa College of Law January 26, 2012 Kathleen Coen Buckwalter , PhD, RN, FAAN Prof. Emerita of Gerontological Nursing

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Overview of Alzheimer’s Disease and Other Dementias

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  1. Overview of Alzheimer’s Disease and Other Dementias Colloquium The Aging Population, Alzheimer’s and Other Dementias: Law & Public Policy University of Iowa College of Law January 26, 2012 Kathleen CoenBuckwalter, PhD, RN, FAAN Prof. Emerita of Gerontological Nursing Co-Director, National Health Law and Policy Resource Center

  2. More than “confusion” • Many things can interfere with memory • Being overloaded; having too much going on at one time • Medications, even ones taken according to directions • Illness and disease that are unrelated to brain disease • Unfamiliar surrounding such as relocation or hospitalization

  3. Dementia • Permanent loss of mental abilities caused by damage to brain cells • NOT a “normal” part of aging! • The common end result of many entities • diseases • traumas • infections • drugs

  4. Dementia: Essential Features Progressive loss of intellectual abilities . . . • MEMORY impairment • Short-term early • Long-term later • Loss of LANGUAGE • Loss of ability to express oneself • Loss of ability to understand what is said

  5. Dementia: Essential Features • Loss of PURPOSEFUL MOVEMENT • Has the physical ability • Can’t perform the task (e.g., getting dressed) • Loss of ability to accurately interpret SENSORY INFORMATION • Cannot understand what is seen, heard, felt • Not related to sensory impairment

  6. Dementia: Essential Features • Impairments in . . . • Abstract thinking • Ability to reason • Judgement • Impulse control • Personality changes • Not “him/herself”

  7. Who has dementia? • Dementia is a “generic term” • Many different types • Alzheimer’s disease  Most common type • Risk increases with advancing age • 13% of 65 year olds • 43% of 85+ year olds

  8. Who has dementia? • Common problem among nursing home residents: 50% to 80% have ADRD • Increasing problem among those in assisted living: 45%-67% residents. Staff training issues, age-in-place

  9. Dementia: Types Types • Alzheimer’s Typea.k.a. Alzheimer’s Disease = Most common • 454,000 new cases annually—public health crisis • 5.4 million Americans afflicted • 6th leading cause of death (all ages) 5th (65+) • 14 million (1 out of 45) by the year 2050 • Approx. 70% of population in nursing homes • Leading cause of behavioral symptoms

  10. Dementia: Types Types • Vascular, a.k.a., Multi Infarct = 2nd most common • Mixed Alzheimer’s AND Vascular = 3rd most common

  11. Dementia: Types Types Dementia due to . . . • HIV Disease • Parkinson’s Disease • Huntington’s Disease • Head Trauma • Substance-Induced Persisting Dementia

  12. Dementia: Types Types Dementia due to . . . • Pick’s Disease • Creutzfeldt-Jakob Disease

  13. Dementia: Types Types • Not specifically listedin DSM-IV . . . • Diffuse Lewy Body Disease • Frontal Lobe Dementia • Many medical causes! • Normal Pressure Hydrocephalus • Anoxic damage • Vitamin deficiency

  14. Dementia: Types Types • Bottom Line: All Alzheimer’s is DEMENTIA . . . but not all DEMENTIA is Alzheimer’s!!

  15. Dementia: Types Types • LOTs of variability in presentation! • Within specific types . . . • BETWEEN types . . . • Overlapping syndromes are common • Dementia AND delirium • Alzheimer’s AND vascular dementia

  16. “Reversible” Dementia • Multiple health problems may cause “confusion” • Always explore alternative causes • Treatment of underlying physical problem may arrest losses • Problems not fully “reversible” but remaining capacity may be preserved

  17. D-E-M-E-N-T-I-A Like working a puzzle . . . D rugs E motion M etabolic E ndocine N utrition T rauma I nfection A lcoholism

  18. Diagnosis of Alzheimer’s:New Criteria and Guidelines • Preclinical Alzheimer’s Disease • Mild cognitive impairment (MCI) due to Alzeimer’s Disease • Dementia due to Alzheimer’s Disease

  19. Stages of Dementia for Behavioral and Environmental Approaches • Early - Forgetful • Middle - Confused • Later - Ambulatory • Terminal - Endstage

  20. Early: Forgetful • Short-term memory impaired • Loses things • Forgets • Blames stress, fatigue • Compensates with lists, memory aids • Depression common

  21. Later: Confused • Loss of memory • Increasing disorientation • Time • Place • Person • Things

  22. Confused: Example • “Helen” crochets using a single simple stitch but doesn’t remember that she is retired - and sometimes puts her bra on over her blouse. • “Harold,” greets everyone like his oldest friend (“Nice to see you! So good of you to drop by! I’m great! How are you?”) but doesn’t know his own wife.

  23. Confused: Example • “Mildred” avoids the question “How old are you?” with “Jack Benny and I are both 29.” When asked what she had for lunch, she replied, “I went to the Riviera and had pink champagne and caviar.” • “George” got lost walking in his neighborhood of 30 years -- as soon as he could no longer see his own house.

  24. Later Still: Ambulatory Dementia • Progressive loss of ability interferes with FUNCTION • Increasingly withdrawn and self-absorbed • Depression tends to resolve

  25. Ambulatory: Functional losses • Willingness and ability to bathe • Grooming • Choosing among clothing • Dressing • Gait and mobility • Toileting • Communication, reading, and writing skills

  26. Ambulatory: Behaviors • Behavioral symptoms more common • Irritability • Agitation • Anxiety • Pacing • Reduced tolerance for stress • Resistiveness to care

  27. Endstage Dementia • All abilities lost • Mute • No longer walks • Little purposeful activity • Forgets to eat, chew, swallow • Complications are common

  28. Symptoms: Not in distinct stages! • Losses and symptoms vary from person to person, depending on • Extent of brain cell death and loss • Location of brain cell death and loss • Speed with which losses occur

  29. Common Behavioral Symptoms • Concealed memory losses • Wandering • Sleep disturbance • Losing and hiding things • Inappropriate sexual behaviors

  30. Common Behavioral Symptoms • Repeating questions • Repetitious actions • Territoriality • Hallucinations • Delusions • Illusions

  31. Agitation Combativeness Confusion Fearfulness Night wakening Noisy behavior Purposeful wandering Sudden withdrawal from activities “Sundowning” Catastrophic Behaviors Unexpected, intense, and “out of proportion” reactions to a situation . . .

  32. Dementia Care Practices • General • Slow down, Eye contact, Cueing • Redirecting, Distracting, Reassurance • Comfort measures (pain meds, food) • Individualized interventions • Promote continuity between levels of care • Pain management • Interdisciplinary team approach • Person vs. Disease focus

  33. Pharmacological Interventions • For mild-mod BPSD non-drug approaches 1st • Psychotropic meds (short term) for severe behav. • Manic sxs: Mood stabilizers (anti-convulsants) • Agitation/agression: SSRIs, mood stabilizers, trazadone • Psychotic sx/severe aggression (danger to self/others) • IM Haldol in crisis. Atypical Antipsychotics • Depressive sxs/anxiety: SSRI antidepressants/benzos

  34. Meds, con’t • Adjunct to non-pharm approaches • Side Effects Black box warnings Off-label • Cognitive Enhancers (Chol. Inhibitors) • Modest benefit • (Donepezil, rivastigmine, galantamine, memantine)

  35. Non-Pharmacological Management of Behavioral and Psychological Symptoms of Dementia (BPSD): First line of defense • Interventions (Individualized/Person vs Disease focus) • No “easy” answers • Complicated by changing clinical course • Principles of Care: • Adjust daily routines • Change reaction/responses to behaviors (redirect, distract, reassure • Monitor and adjust the environment, remove triggers • Adjust interaction and communication strategies: slow down, eye contact, cue • Comfort measures (food, pain, toilet)

  36. Non-Pharmacological Management, cont’d • Cognitive training: Early Stage • Cognitive stimulation, memory rehab, R.O., Neuropsychological Rehabilitation • Structured Activities • “Simple Pleasures” • Recreational • Physical (exercise and movement)

  37. Non-Pharmacological Management, cont’d • Socialization • Pets • Reminiscence, R.O. • Video Respite • Simulated Presence Therapy • Sensory Enhancement/Stim • Expressive Arts • Music • Aromatherapy • Snoezelen

  38. Summary • Alzheimer’s disease is INCURABLE, but not UNTREATABLE! • Preserve & enhance remaining abilities • Avoid unnecessary stress & overstimulation • Treat illness or other complications • Provide education & guidance for families and other caregivers

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