Glutathione - Their role in cancer and Anticancer Therapies

1. Glutathione Their role in cancer and Anticancer Therapies Quicksilver Scientific

2. Because your body needs a Regular supply of this critical substance and how you can help Prevent cancer, treat Existing cancers, and Beating effects Adverse of the Chemotherapy and Radiation. The role of glutathione in cancer and ANTI-cancer therapies Glutathione is the essential antioxidant for body health help, a strengthener and Immune stimulant. This small protein, naturally produced in the body, keeps these three protective functions. What's more, your life depends on the glutathione. Without it, your cells will disintegrate by Irrefrenada oxidation, your body would have little resistance to bacteria, Viruses and cancer, and your liver would be dried by accumulation of toxins. Glutathione is not an ordinary word yet. Even doctors who hear the word they might have a vague idea of her. However, everyone will soon be talking about this crucial substance. There was a time when only scientists had heard about cholesterol and vitamins, but everyone knows it today. Now is the Glutathione's turn. Over the last five years, more than twenty-five thousand articles Physicians about this substance have been published and this scientific understanding is gradually becoming common knowledge. Each cell in the body is responsible for its own supply of Glutathione, and must have the necessary materials to do so. Glutathione is always in great demand and is consumed quickly when we experience any kind of challenge – sickness, stress, fatigue and even exercises. Some Known causes of glutathione depletion are shown in Figure I. The Glutathione levels also decay as we age and many Diseases normally associated with ageing have been linked to the Glutathione deficiency. Because glutathione is essential to health The three main roles of glutathione in the body are summarized by the letters A-I-D – Antioxidant, immune-stimulating, and detoxifying-three critical processes carried out by Glutathione.

3. The antioxidant Master (AID) In the last thirty years researchers have explored the value of antioxidants in the good Health, as well as the treatments and prevention of diseases involving attacks Oxidative by free radicals. This has produced a whole new branch in the MedicinaBiología of free radicals. Free radicals have been implicated in all kinds of Diseases, including heart disease, diabetes and aging as such. Known and widely used antioxidants such as vitamin C, vitamin E and Selenium Neutralize free radicals. They are present in nature, but not naturally in your Cells-should be introduced as part of a balanced diet. Given the crucial role of Antioxidants in good health, it is not surprising that the body creates its own antioxidants Natural. The most important of these is glutathione. Because all the other antioxidants depend on the presence of glutathione to function properly, scientists call it "the Antioxidant master.” Food for the immune system (AID) The function of the immune system is to identify and attack germs and other invaders, including cancer cells. A body full of glutathione fights these threats a lot More easily by denying them something to hold on to and confront the few who manage to enter with a high immune system. High glutathione levels allow the body to produce more White blood cells-the most important line of defense in the immune system. Glutathione plays a central role in the functions of these immune cells. An expert in glutathione says, "the limiting factor in the correct activity of our lymphocytes (white blood cells) is the availability of glutathione.” In other words, a growth Healthy and immune cell activity depend on the availability of glutathione. Simpler yet, glutathione is ' food ' for our immune system. Natural detoxifying (AID) Whether we know it or not, we are continually inhaling and ingesting natural toxins and Synthetic. Are inevitable in these modern times, both in our polluted cities as in our processed foods. When the body has health and nutrition that it requires work incessantly to eliminate toxins and to protect itself. But rising levels of environmental pollution are depleting the stock of glutathione more and more quickly. Our main detoxifying organ is the liver-the most concentrated source of glutathione in the body. Studies show that low levels of glutathione lead to poor functioning of the liver, causing more and more toxins to circulate through the body resulting in damage to Cells and organs. Doctors commonly use glutathione- promoting drugs to Deter victims of certain drug overdoses. Glutathione in Natural medicine Complementary medicine practitioners have prescribed "milk thistle" for problems of Liver. It turns out that this herb works modestly elevating levels of glutathione. The Mineral selenium also produces subtle increments of glutathione by being integrated into the enzyme Glutathione peroxides.

4. Glutathione in conventional medicine Emerging physicians, toxicologists and lung and liver specialists are well acquainted with the therapeutic applications of the glutathione. American physicians in seeking ways to Elevating glutathione levels can open the physician's reference book (Physicians Desk Reference-PDR) and find two options-the pharmaceutical drug NAC (n-Acetyl-cytokine), Sold under the name of Mucosal and Mucomyst, and the natural supplement HMS 90 (Immunocal) An isolated whey protein patented. Drugs that elevate levels of glutathione Pharmaceutical drugs as shown in Figure 2 have been used to elevate levels Glutathione. However, they all produce side effects that do not allow them to be for the Long-term use. The NAC drug is a potent precursor of glutathione that has been within reach for many years, and is also located on the shelves of health supplement stores. This pharmaceutical chemist is used to break mucus in lung diseases such as cystic fibrosis, chronic bronchitis and asthma. Still remains as a treatment Standard for Acetaminophen overdose. Most of the traditional studies of Glutathione in humans have been conducted with NAC. NAC therapy has two common problems: first, it's a pharmaceutical drug and Contains certain toxicity in SI; Second, NAC-induced glutathione levels reach a Peak quickly and decay in a few hours. The drug is described as a drug that it’s short lived. Rapid peaks are commonly followed by a sudden fall, often lower to normal levels. To consistently maintain elevated levels of glutathione, NAC It should be consumed or injected several times a day, and this is very hard for the organism. Many people taking NAC report symptoms that include purity, nausea, vomiting, Cramps and diarrhea. Others find that the smell and taste are unacceptable. Although rarely, Death has been reported in association with NAC. However, it is still the most commonly used to elevate levels of glutathione in clinical environments. OTC (ornoithine decarboxylase, Procysteine), OTZ (Oxothiazolidine carboxylate), monomats of glutathione and Di glutathione are all synthetic compounds with a skill Limited to elevate levels of glutathione and have not shown security records. Natural products that elevate levels of glutathione Oral Glutathione A variety of chemical enterprises package the glutathione itself in pills or powder, But this is not particularly the best way to help the body. A small amount of Glutathione can make his way to the bloodstream, but the majority is lost during the Digestive process and cannot effectively elevate intracellular levels of glutathione. Can To lead to a possible decrease in total glutathione in the organism. Cysteine (L-cytokine) Cysteine, available through pharmacological providers and in health stores, can elevate Intracellular levels of glutathione to some extent but it is oxidized in the digestive tract and Enter the bloodstream with difficulty. The toxicity of cytokine is well described in the Medical literature.

5. Methionine (L-methionine) The essential amino acid methionine is present in many foods and has been identified as a precursor to glutathione. But it is also a precursor of homocysteine, recently Recognized as a high risk factor in the development of arteriosclerosis (hardening of arteries). Melatonin Melatonin is known for its role in regulating the cycles of sleep and awakening and is Popular for its jet lag treatment, insomnia or other sleep disturbances. These benefits can be explained by the ability of melatonin to elevate levels of glutathione in the Brain, liver, muscle, blood serum and other tissues. However, the response of the Body to melatonin varies greatly from one person to another, and its long- term security has not been established. This product should only be used under the guidance of a professional of health. Glutamine Both taken orally and intravenously, glutamine supplements concentrations Higher glutathione, but completely healthy individuals should not require the Glutamine supplementation and may lead to gastrointestinal side effects. People of more Age as well as liver and kidney patients should be cautious. Any serious use of this Supplement should be monitored by a health care professional. Lipoid acid Lipoid acid occurs naturally in the pro body is also found on shelves of Health stores. It is known that as glutathione molecules neutralize free radicals Gradually oxidize, but lipoid acid can re-load its antioxidant powers to Convert it back to a reduced form. It's still being investigated by scientists. Silymarine (Milk Thistle) The plant of Silybum Mariana has a long history in the treatment of problems of Liver. It clearly prevents the oxidation of fats and maintains levels of glutathione, but Possible toxic reactions including gas, cramps and diarrhea. Liver disease not They should never be treated without the supervision of a health professional.

6. Whey proteins Serum, a large group of proteins, is a constituent of milk of humans and other mammals, And under ideal circumstances it contains the forerunners of glutathione. Many serum products are marketeados to health conscious people but vary in Large extent in its protein content, in its concentration, in the forms of protein present, and other factors that affect the bioactivity of the product (biological action). Perhaps the criterion Most important of all is the measure of the protein denaturation of the product-a Breakdown in protein structure. This reduces your potential bioactivity in the body without affecting Its nutritional value. In addition, many nutritionists say that the fat or dairy content of Whey protein products may be too high to worry about. Others have reservations about the milk industry and their liberal use of antibiotics and steroids To increase production. Nor can we ignore the actual amount of fat toxins Soluble and soluble water that pass into milk. The really cool buttermilk contains So potent precursors of glutathione such as lactoferrin, beta-lactalbumin and serum Albumin son Easily denatured by heat and mechanical agitation. Pasteurization and others Industrial processes tend to denature dairy products and until they reach their Table your bioactivity will be lost. To maintain the bioactivity of the precursors of glutathione serum proteins should be Extracted from milk with special means, careful monitoring is essential. Products of Serum may contain between 20% and 90% of protein. These proteins vary greatly as well As well as in the way their precursors of glutathione are denatured. So Although some proteins are bioactive, most are not. Glutathione in Health and disease It is thought that glutathione has a potential role in the treatment and prevention of hundreds of Diseases. In the future it could be considered as important to health as a Balanced diet, exercise and a good lifestyle. Clinical studies show that Raising levels of glutathione can solve some of the health problems of our Times like heart disease, heart attacks, diabetes, high cholesterol, and asthma, smokers, Hepatitis, ALDS and more. Glutathione provides the body with tools to combat these Threats in a natural way. Healthy people also benefit from elevated levels of glutathione through a Strong ability to combat toxins, infectious diseases, PRE-cancer cells and The aging process as such. Decreased levels of glutathione are a consequence Of the ageing process and particularly evident in conditions such as Parkinson's disease and Lazier. Glutathione is also important to physically active people. Many athletes are Discovering that well maintained levels of glutathione give them an advantage over their Competitors, bringing more strength and resistance, with less time to recover Injuries, less muscular pain and fatigue, providing good muscular activity.

7. Coupled parts Medical science is still investigating all the critical roles played by the Glutathione in disease resistance and good health in general. Evidence Clinic Associates low levels of glutathione with the most common diseases of Our time as well as new emerging diseases. As an Essential health help, glutathione functions as the Antioxidant Master in our body, optimizing our immune system and Detoxifies A long list of pollutants and carcinogens. However, the levels of glutathione In the body are not elevated by eating glutathione, as it is poorly absorbed By our digestive system. It must be manufactured inside the cells of the body. Therefore, the best way to elevate glutathione levels is by supplying the Precursors used by the cells for themselves to manufacture. Pharmaceutical medicine has created drugs that make it very efficient and use it in Critical situations. But they also have side effects and their repeated use this contraindicated. Recently, scientists have studied natural ways to elevate levels of Glutathione by means of safe and reliable food. The emergence of proteins from Bioactive Serum is an important step towards nutritional supplementation. Cancer What is cancer? Cancer is an increase in abnormal growth of certain cells or tissues in our body. This growth can over populate our vital organs, affect their functions and consume Energy reserves. More than a hundred types of cancer are known, some spreading more quickly than others. Many treatable and even curable. However, it remains as second guilty of death in North America-only cardiovascular diseases produce more deaths. A third of America will eventually die of some kind of cancer. Many Cancers can be prevented by a diet, avoiding carcinogens and reinforcing the body's defenses. How does cancer develop? Healthy cells have mechanisms that in states of good health allow them to multiply for three purposes: normal growth, healing of the injured tissue and Replacement of lost cells by normal use. However, under certain conditions that even we don't fully understand, this mechanism gets twisted. Cell growth is May return irregularly, leading to an uncontrollable retort which forms agglomerations of Tissues-a tumor. Tumors grow and can release individual cells into the systems in the bloodstream, spreading the disease to other parts of the body and creating new tumors through the metastasis process. Depending on your size and Location, a tumor eventually takes the place of the healthy tissue itself, interfering with the Functions of the organism and consuming energy reserves, producing symptoms that eventually they take us to the doctor's office.

8. That triggers the cell to become carcinogenic? It is not clear precisely how cells and because cells lose self-regulation and they become carcinogenic, although many possible causes have been identified. Many Carcinogenic in the environment are known to promote cancer growth, especially certain chemicals and high levels of radiation. Oxidative Stress and free radicals they play an important role in many theories. Other factors are less predictable. Variations In our genetics or immune system apparently protect some people while others fall as victims. We also know that susceptibility to certain cancers is inherited by family or ethnicity, but gatillantes elements are still missing to be clarified. What can cause cancer? Many genetic and environmental causes of cancer have been identified, from genes Recessive to well- identified toxins. Even the aging process increases our Risk. The onset of cancer is characterized by a mutation in the genetic code of the Cell-a reprogramming of developing patterns resulting in a growth Uncontrolled. A combination of genetic and environmental factors-including Food-can contribute to being aberration. One theory states that when free radicals are formed in the nucleus of the cell, the code Of the DNA can be damaged. Another theory says those factors as poor diet and the immune system and weakens the body's defenses that could have defeated the onset of cancer. Independent of the theory, we should take advantage of all possible factors, one that is the modulation of the glutathione. What is the connection between glutathione and cancer? Glutathione helps us fight cancer in at least three ways: first and foremost important, it can prevent the development of cancers first of all. Second, glutathione tends to to combat already established cancers in the body. Finally, it can alleviate many of the Consequences of cancer, including weight loss, and the side effects of the Chemotherapy and radiotherapy.

9. Prevention Antioxidant defense against DNA mutation Free radicals are pro-oxidants, a normal bi-product of production of Energy and other cellular activities. They can cause DNA mutation. An article of 1996 in the Journal of Cancer suggests that free radicals be listed as an important class of carcinogens. As the most important cell antioxidant, glutathione neutralizes the effect damaging of free radicals--especially oxidizing radicals--as soon as they they form in the cell. Glutathione has the additional benefit of increasing the effect Antioxidant of vitamin C, E and selenium, each of which plays a role Particular in the fight against free radicals. Glutathione not only prevents mutation Of DNA, it can also repair damaged DNA and contribute to the creation of new DNA. Increased immune response Glutathione is a crucial player in the immune system and is directly involved in replicating and growing T-lymphocytes-a type of blood cells Targets who attack specific disease agents and help coordinate the Wide response of the body. Low levels of glutathione lead to an activity Inadequate T-cells. As has been seen in AIDS patients who are particularly susceptible to a type of cancer called "Kaposi Sarcoma ", a cancer in which a healthy immune system is resistant. Detoxification of CANCERIGENOS In addition to being a powerful antioxidant, glutathione is also a detoxifying, known to neutralize and/or eliminate a well-documented number of Cancerigenos and mutagens. It is not surprising that glutathione is more concentrated in the liver, the body's main detoxifying organ. Elevated levels of glutathione have proven to be very effective in defending against cancer. The Chemotherapy branch of the U.S. National Cancer Institute has been developing drugs, over the past decade, which helps to reduce the incidence of cancer. These weapons Powerful in their arsenal are NAC- a potent drug that raises the levels of glutathione in the Body-and Selenomethionine-a selenium derivative with similar effects. A development has shown that a nutritional supplement with selenium reduces the chances of Get prostate cancer. Other studies have shown the role of selenium protection against Cancer of the colon, rectum and lung as well as colon polyps. American and European researchers including R.M. Blanks, D.C. Conaway and A. Wits chi have successfully demonstrated that NAC inhibits the types of toxin-induced cancers such as "Urethane, Nitrosamines, doxorubicin and Ethylnitrosourea" (in English). Good news in NAC's ability to protect against the cancerous properties of the Cigarette. N. Van Sandwich from the Netherlands Cancer Institute writes: "NAC has emerged as a promising agent of cancer-prevention.” A large-framed prevention trial sponsored by "Project screw up" measured the potential use of NAC against lung, breast, and stomach and skin cancer. The results led to Favorable comments from Side Flora, who noticed many positive mechanisms and effects of NAC and glutathione in cancer prevention.

10. Low levels of glutathione, promote cancer? Glutathione is a component of several enzymes, each of which plays a particular role in the Defense system the organism. A study published in the Journal of the National cancer Institute "observed one of this enzymes-glutathione-S tranferase-mu-1 (GSTM1)-which appears Manufactured by the body according to the pattern stored in a specific gene. It appears that two people one inherits two defectives copies of the GSTM1 gene and that 25% of cancers to the Bladder can be attributed to the poor functioning of that gene. The GSTM1 enzyme is an Antioxidant that also detoxifies common bladder carcinogens such as smoke from Cigarette. Other studies show that another enzyme of glutathione-glutathione-S-transferase-pi-1 (GSTP1) is Almost always absent in men with pre-cancerous or prostate cancer conditions. It seems that the lack of this glutathione enzyme makes the cancer stay in the Gondola Prostate more easily and several studies confirm this. But the lack of other Glutathione enzymes has been linked to the onset of breast and lung cancers, especially in smokers. For these reasons, a growing number of scientific doctors Suggest that men and women be checked for enzyme deficiencies--and even genetic defects that produce it-as a way of determining more precisely the Risk of cancer of an individual. If certain cancer cells are high in glutathione, raising levels of glutathione not Will it make cancer stronger? Many types of tumors have large amounts of glutathione, a factor that can make them Resistant to chemotherapy and radiotherapy. However, cancers cells have lost their ability to auto regulate the growth of other metabolic functions. One thing that does not perform well is to regulate the metabolism of the glutathione. When cancer cells are exposed to large quantities of precursors of glutathione, stop the production of Glutathione. This is what scientists call "down" regulation or negative feedback Inhibitory. Healthy cells don't react the same way. How can increased levels of glutathione help fight cancer? By using the appropriate precursors, glutathione levels may selectively increase In normal tissues and depleted in cancer cells, making in turn that the cells Cancers are more susceptible to damage and elimination by the immune system. How can increased levels of glutathione help in chemo and radiation? In the same way that lowering the levels of glutathione in cancer cells makes them more Susceptible to damage, including chemotherapy and radiation, high levels of glutathione in cells Healthy makes them more resistant to treatment. We see it illustrated on the back cover of the Brochure. This leads to fewer side effects such as nausea, vomiting, diarrhea, loss of Hair and even the loss of white blood cells (leucopenia). Glutathione modulation represents an original approach in the treatment and prevention of cancer. Oral forms of glutathione do little to elevate intracellular levels of Glutathione. Intravenous glutathione has proven its benefits. Sources both pharmacological and Nutritional precursors of glutathione have proven their effectiveness. Patients with higher levels of intracellular glutathione

11. experience much less adverse effects of chemotherapy. In addition, people with higher levels of glutathione Figure 5 – How glutathione helps prevent and fight cancer GENETIC factors Ant oxidation Toxins Free radicals Radiation Aging Other antioxidants Glutathione Enzyme deficiencies Detoxification Cancerigenos agents Mutant agents Immune modulation Activity Cellules T-cell Treatment Immunotherapy Anti-cancer activity Mitigating Adverse effects Chemotherapy Radiotherapy They have more protection against radiation damage, in turn reducing the adverse effects of Radiation therapy. Radiotherapists who have investigated the role of glutathione in the protection of cells have Able to correlate treatments of high glutathione levels with a lesser amount of Burns sustained after radiation. PRE-Treatments or simultaneous treatments for Elevating glutathione consistently demonstrate a better tolerance to therapy. Glutathione and the immune system against cancer Glutathione helps the immune system in several ways. First by facilitating growth and Functioning of the white blood cells, who are aggressively damaged by the Anti-cancer treatments, and elevates the immune system's ability to combat directly. A new anti-cancer strategy uses "immunotherapy"-ways to elevate capacity Natural immune system to fight cancer. A team from the University of Kyoto in Japan demonstrated that NAC increased the stimulus to immune cells and their products Biochemists when added to "Cytokines" – a class of immunotherapeutic agents. Also they suggest that this can be an effective adjunct to the treatment of liver cancer. Other anti-cancer substances naturally produced by the immune system include several types of tumor necrosis factors (TNF) and IL-2 (Interleukin 2). Scientists in "Glico Welcome Research and Development" postulated a hypothesis that the drug that Increases the lunation NAC fights tumors by increasing the action of TNF and demonstrated as its use prevents the development of cancer in a third of mice injected with malignant cells. S. Yam and D. Hobbs of UTA University were also successful in suppressing Growth of tumors by stimulating IL-2 in killer cells. Glutathione in surgery and recovery The surgery itself releases trillions of free radicals, while anesthesia and other drugs carry Additional dangers. The role of glutathione as an antioxidant and detoxifying can decrease the Threat. Higher levels of glutathione also accelerate the healing process and reduce Possibility of post-surgery infections.

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