Figure 1 A cluster of BMI-associated SNPs in the first intron of FTO

Nov 29, 2014

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Figure 1 A cluster of BMI-associated SNPs in the first intron of FTO. Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO —the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227.

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Figure 1 A cluster of BMI-associated SNPs in the first intron of FTO

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Figure 1 A cluster of BMI-associated SNPs in the first intron of FTO Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO—the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227

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Figure 1 A simplified schematic of the metabolism of thiopurines

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Figure 1 A

Figure 1 A.

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Figure 1: The House of Quality

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Figure 3 Hypothetical role of FTO in amino-acid sensing

Figure 3 Hypothetical role of FTO in amino-acid sensing. Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO —the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227.

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Table 1 Effect size and explained variance of BMI-associated FTO SNPs

Table 1 Effect size and explained variance of BMI-associated FTO SNPs. Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO —the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227.

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Figure 1 Functions of the proteins encoded by the 12 HSAN-associated genes in sensory neurons

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Supplementary figure 1. A schematic figure of the three-segmented RVFV genome

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Excision of Intron Sequences

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Supplemental Figure 1A: RAW BMI MALES

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Figure 1 The timeline of development

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Computational prediction of damage associated non synonymous SNPs of CYP17A1 and CYP19A1 gene

The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 and CYP19A1 are the key proteins involved in steroidogenesis. Majority of polymorphisms have yet not been evaluated for their possible damaging effects on protein structure and function of both the genes. In present analysis, we tried to find out the effect of damage associated nsSNPs of both CYP17A1 and CYP19A1 gene by using various computational algorithms. Out of 205 and 246 nsSNPs reported for CYP17A1 and CYP19A1 gene, total 13 and 7 were predicted to affect the structure and function respectively. R125Q, R416H and F453S substitutions of CYP17A1 gene were not reported previously hence provide the new dataset of unexplored SNPs for their validation. By our results we also found that substitution of mainly Arginine or Phenyl alanine within conserved domain of redox binding, heam binging and redox partner site would cause partial or complete loss of function of both CYP17 and CYP19 gene. Richa Bhatnager | Ranjeet Kaur | Amita Suneja Dang | Twinkle Dahiya "Computational prediction of damage associated non synonymous SNPs of CYP17A1 and CYP19A1 gene" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: https://www.ijtsrd.com/papers/ijtsrd3581.pdf Paper URL: http://www.ijtsrd.com/biological-science/biotechnology/3581/computational-prediction-of-damage-associated-non-synonymous-snps-of-cyp17a1-and-cyp19a1-gene/richa-bhatnager

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The informatics of SNPs and haplotypes

The informatics of SNPs and haplotypes. Cold Spring Harbor Laboratory Advanced Bioinformatics course October 17, 2005. Gabor T. Marth. Department of Biology, Boston College marth@bc.edu. cause inherited diseases. allow tracking ancestral human history. Why do we care about variations?.

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