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10 9

10 10. 10 10. 10 10. 10 10. 10 10. 10 10. 10 9. 10 9. 10 9. 10 9. 10 9. 10 9. +tet 212 h. -tet. 10 8. 10 8. 10 8. 10 8. 10 8. 10 8. cells ml -1. cells ml -1. cells ml -1. cells ml -1. cells ml -1. cells ml -1. 10 7. 10 7. 10 7. 10 7. 10 7. 10 7. 10 6. 10 6. 10 6.

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10 9

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  1. 1010 1010 1010 1010 1010 1010 109 109 109 109 109 109 +tet 212 h -tet 108 108 108 108 108 108 cells ml-1 cells ml-1 cells ml-1 cells ml-1 cells ml-1 cells ml-1 107 107 107 107 107 107 106 106 106 106 106 106 105 105 105 105 105 105 2C -tet +tet 72 h 2C 4C 4C -tet +tet 240 h 100 -tet 2C +tet 108 h 80 2C +tet 216 h 60 % cells 4C 4C 1010 2C -tet +tet 115 h 40 2C 2C 109 2C 20 108 cells ml-1 4C 107 4C 0 4C 4C 106 1N1K 1N2K 2N2K 0N1K 2N1K other 105 +tet 192 h -tet 2C 2C 4C 4C clone 8 -tet +tet 212 h 2C 2C 4C 4C clone 13 -tet +tet 192 h 2C 2C 4C 4C clone 33 clone 44 clone 45 clone 135 clone 153

  2. 1010 1010 1010 1010 1010 1010 109 109 109 109 109 109 108 108 108 108 108 108 cells ml-1 cells ml-1 cells ml-1 cells ml-1 cells ml-1 cells ml-1 107 107 107 107 107 107 106 106 106 106 106 106 105 105 105 105 105 105 2C 2C 4C 4C -tet +tet 216 h 2C 4C 4C 2C 8C -tet +tet 192 h 2C 2C 4C 4C +tet 192 h -tet 2C 2C 4C 4C -tet +tet 192 h 2C 2C 4C 4C +tet 192 h -tet 2C 2C 4C 4C -tet +tet 192 h clone 165 clone 174 clone 187 clone 209 clone 211 clone 223

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