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Hantavirus Evolution and Transmission: A Comprehensive Study

Explore the viral evolution and transmission of hantavirus among reservoir hosts and humans. Learn about the replication process, immune system response, and the deterministic and stochastic models. Study the hantavirus structure and phylogenetic tree analysis.

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Hantavirus Evolution and Transmission: A Comprehensive Study

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  1. Hantavirus: Viral Evolution Chelsea, Zuania, Keerthana, Eduardo

  2. Transmission of hantavirus among reservoir host and humans

  3. Transmission of hantavirus • Once the hantavirus has entered a species one of four events can occur: • infect an epithelial cell • remain a free virus • eliminated by a natural killer cell • intercepted by an antigen presenting cell

  4. Compartmental diagram of the activation of the immune system in response to an antigen

  5. Replication of hantavirus • Subgenomic • replicates in parts rather than one piece • hantavirus: tripartite (3 parts) • Largest strand • viral polymerase • Smallest strand • N, NS protein • Uses nsRNA genome as a cap snatching device • steals end of host mRNA genome • migration of newly formed hantaviral proteins

  6. Deterministic Model (ODEs)

  7. Conceptual Diagram

  8. Stochastic Model (SDEs) • Adds Brownian motion

  9. Quasispecies (viral evolution) • Each time the virus infects a cell and begins to replicate, changes in its genome occur • No phenotypic effect • behaves like the wild-type virus • Phenotypic effect • new viruses to the antigen-specific immune responses • new CTL and antibodies specific to the new virus

  10. Quasispecies (viral evolution)

  11. Quasispecies Model

  12. Hantavirus Structure • We used PlyMol! • Crystal structure of the N-terminal domain of the strain 1-75 nucleoprotein

  13. Hantavirus Structure • PlyMol again! • Crystal structure of the N-terminal domain of the strain 76-118 nucleoprotein

  14. Phylogenetic Tree

  15. Selected References • L. J. S. Allen. An Introduction to Stochastic Processes with Applications to Biology. CRC Press/Chapman Hall, Boca Raton, FL, 2nd edition, 2010. • G. Schonrich, A. Rang, N. Lutteke, M. J. Raerty, N. Charbonnel, and R. G. Ulrich. Hantavirus-induced immunity in rodent reservoirs and humans. Immun. Rev., 225:163{189, 2008. • Wordle, phylogeneticdata: http://www.ncbi.nlm.nih.gov/

  16. The End Or is it

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