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Hematopoiesis Simplified: Part 1 Erythropoiesis. Larry Johnson Texas A&M University. Hematopoiesis Simplified: Part 1 Erythropoiesis. Objectives are to: Identify the developmental cells of erythropoiesis
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Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 1 Erythropoiesis Objectives are to: • Identify the developmental cells of erythropoiesis • Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow 32583 Blood vessel
19761 Bone marrow Blood in vessel
Peripheral blood 21 Erythrocytes Reticulocytes
Erythropoiesis Erythrocytes No nucleus and red cytoplasm Reticulocytes No nucleus and blue - grey cytoplasm Dark, small, spherical nucleus blue – grey cytoplasm Orthochromatophilic erythroblasts Darkening, fractured ,spherical nucleus and mixed pools of grey and blue cytoplasm Polychromatophilic erythroblasts Fractured, spherical nucleus and thin rim of dark blue cytoplasm Basophilic erythroblasts Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm Proerythroblasts
Erythropoiesis Proerythroblasts Erythrocytes Reticulocytes Orthochromatophilic erythroblasts Basophilic erythroblasts Polychromatophilic erythroblasts Erythropoiesis
Orthochromatophilic erythroblasts Erythrocytes
Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis
Polychromatophilic erythroblasts
Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis
Basophilic erythroblast
Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis
Erythropoiesis Orthochromatophilic erythroblasts Erythrocytes Reticulocytes
Earlyorthochromatophilic erythroblasts Latepolychromatophilic erythroblasts
Polychromatophilic erythroblasts Earlypolychromatophilic erythroblasts
Basophilic erythroblasts Proerythroblasts
ut 112 Orthochromatophilic erythroblasts RBCs Latepolychromatophilic erythroblast Basophilic erythroblast platelets Polychromatophilic erythroblast Reticulocyte Erythrocytes Eosinophil or basophil Proerythroblast
Bone marrow Reticulocyte entering blood vessel Blood vessel 32583
The End of Hematopoiesis Simplified: Part 1 Erythropoiesis
Hematopoiesis Simplified: Part 2 Granulopoiesis Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 2 Granulopoiesis Objectives are to: • Identify the developmental cells of granulopoiesis • Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow 32583
19761 Bone marrow Blood Blood
` 32583 Bone marrow Developing granulocytes
Granulopoiesis Lobulated, dark nucleus, mature grey cytoplasm with small granules Neutrophils Neutrophilic band or stab cells Horse-shoe shaped, darkening nucleus, grey mature cytoplasm Neutrophilic metamyelocytes Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules Neutrophilic myelocytes Large, oval, non-indented nucleus, large amount of sky blue cytoplasm with non-specific granules Promyelocytes
Granulopoiesis Neutrophils Promyelocytes Neutrophilic band cells Neutrophilic myelocytes Neutrophilicmetamyelocytes
ut 112 Neutrophil Neutrophilic metamyelocytes Neutrophilic metamyelocyte Platelets Eosinophil or basophil Neutrophilic myelocytes
Neutrophils Promyelocytes Neutrophilic band cells Neutrophilic myelocytes Neutrophilicmetamyelocytes Granulopoiesis
Neutrophilicmetamyelocytes Lymphocytes Neutrophilicmyelocytes Unknown nuclei Promyelocyte Neutrophilic band cells Lymphocytes Neutrophilic myelocytes Neutrophilic band cells Neutrophilic metamyelocytes Neutrophilic band cell
Neutrophilicband cells Neutrophils Granulopoiesis
Neutrophilic metamyelocytes Earlyneutrophilic metamyelocytes
Latepromyelocytes Promyelocyte
Neutrophilic metamyelocytes Unknown nuclei Neutrophilic myelocytes Neutrophilic band cells Neutrophilic metamyelocytes Proerythroblast Orthochromatophilic erythroblasts Orthochromatophilic erythroblasts Eosinophils or basophils
Bone marrow 32583 White blood cell entering a blood vessel Blood vessel Blood vessel