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Long-term Potentiation as a Physiological Phenomenon

Long-term Potentiation as a Physiological Phenomenon. From Mechanisms of Memory by J. David Sweatt, Ph.D. The Entorhinal/Hippocampal System. Entorhinal Cortex. Perforant Pathway. Dentate Gyrus. Stratum Lacunosom Molecular inputs. Mossy Fiber. Lateral Septum, Contralateral CA1.

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Long-term Potentiation as a Physiological Phenomenon

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  1. Long-term Potentiation as a Physiological Phenomenon From Mechanisms of Memory by J. David Sweatt, Ph.D.

  2. The Entorhinal/Hippocampal System Entorhinal Cortex Perforant Pathway Dentate Gyrus Stratum Lacunosom Molecular inputs Mossy Fiber Lateral Septum, Contralateral CA1 CA1 Axon CA3 Schaffer Collaterals Recurrent Connections GABAergic Interneuron Ipsilateral CA1 Norepinephrine, Acetylcholine, Entorhinal Cortex Dopamine, Amygdala, Cortex Serotonin SLM Inputs Schaffer Collaterals Lateral Septum Subiculum

  3. Bliss and Lomo’s First Published LTP Experiment

  4. Electrodes in a Living Hippocampal Slice Stimulating Electrode Recording Electrode

  5. Recording Configuration and Typical Responses in a Hippocampal Slice Recording Experiment Recording in Stratum Pyramidale in Area CA1 Stimulating Schaffer Collaterals in Area CA3 Recording in Stratum Radiatum in Area CA1 Stimulus Artifact Fiber Volley EPSP

  6. An Input/Output Curve and a Typical LTP Experiment A B

  7. APV fEPSP slope (% of baseline) Time (min) APV Block of LTP Figure 6: APV Block of LTP

  8. A 100-Hz 100-Hz 100-Hz 100-Hz 200 msec … 200 msec 200 msec 10 msec between pulses • 5-Hz burst frequency • 10 bursts per train • 3 trains, 20-sec intertrain interval B 200 175 150 fEPSP slope (% of baseline) 125 100 75 -20 0 20 40 60 Time (min) LTP Triggered by Theta Burst Stimulation

  9. Pairing LTP

  10. Coincidence Detection by the NMDA Receptor Cytoplasm Synaptic Cleft Synaptic Cleft Cytoplasm - - - - - - + + + + + + Ca++ Gly Gly Ca++ Mg++ Ca++ Mg++ Glu + + + + - - - - + + + + - - - - Glu Glutamate plus Membrane Depolarization Synaptic Glutamate Alone

  11. Back Propagating Action Potentials

  12. Timing of Back-propagating Action Potentials with Synaptic Activity

  13. The Dendritic Tree and Regulation of Action Potential Propagation A B NE Change in Local excitability 1 Synaptic Activity 2 EPSP’s LTP? Synapse

  14. NMDAR independent LTP A C B

  15. PPF PTP

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