1 / 1

Purpose

Long-Term Experience With Neoadjuvant Concurrent Chemo- Radiotherapy For Locally Advanced Rectal Cancer Using Oral UFT And Leucovorin. Konstantin Lavrenkov, Keren Rouvinov, Sofia Man, Shlomo Walfisch, Ilia Pinsk, Tatiana Charkovski, Ignatio Sztarker , Samuel Ariad.

ranger
Download Presentation

Purpose

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Long-Term Experience With Neoadjuvant Concurrent Chemo- Radiotherapy For Locally Advanced Rectal Cancer Using Oral UFT And Leucovorin Konstantin Lavrenkov, Keren Rouvinov, Sofia Man, Shlomo Walfisch, Ilia Pinsk, Tatiana Charkovski, Ignatio Sztarker, Samuel Ariad Soroka University Medical Center and The Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel Barzilai Medical Center, Ashquelon, Israel Patients and methods Patient characteristics (absolute / per cent) Variable Patient number Patient number 31 Age (years) Median 64 Range 36 - 79 Gender Male 20 / 64.5 Female 11 / 34.5 Clinical stage II 10 / 32.3 III 21 / 67.7 Distance from anal verge, cm 0 – 5 16 / 51.6 >5 – 10 12 / 38.7 >10 3 / 9.7 • Staging procedure • Trans-rectal ultrasound • Whole body Ct-scan • Colonoscopy • Total dose – 6-10 Gy • Preoperative radiotherapy regimen • 2 Gy daily • 5 fractions per week • Total dose • Entire pelvis – 44 Gy • Boost to tumour and • affected lymph nodes – 6 Gy • Preoperative chemotherapy regimen • UFT 240 mg/m2/day • Leucovorin 60 mg/m2/day • Surgery • Anterior resection or abdomino- • perineal resection • Total mesorectal excision Adjuvant chemotherapy (total / per cent) Regimen Patient number Bolus 5FU – Leucovorin 12 / 38.7 Protracted 5-FU - Leucovorin 1 / 3.2 UFT – Leucovorin 7 / 22.6 FOLFOX 1 / 3.2 No 10 / 32.3 Results Toxicity (absolute / per cent) Variable Grade 1-2 Grade 3-4 Hematologic Anemia 7 / 21.9 0 / 0 Neutropenia 0 / 0 0 / 0 Thrombocytopenia 1 / 3.1 0 / 0 Gastro-intestinal Vomiting 1 / 3.1 0 / 0 Diarrhea 6 / 18.8 5 / 15.6 Rectal 11 / 33.5 0 / 0 Skin 19 / 71.9 1 / 3.1 Sphincter preservation (absolute / per cent) Distance from Anterior resection anal verge, cm rate 0 – 5 9 / 56.3 >5 – 10 12 / 100 >10 3 / 100 Total 24 / 77.4 5-year – 87% Purpose To evaluate experience of neoadjuvant concurrent chemo-radiotherapy using oral UFT and leucovorin given to patients with locally advanced adenocarcinoma of rectum. Conclusion To our experience, neoadjuvant concurrent chemo-radiotherapy containing UFT and leucovorin is safe and effective treatment for patients with locally advanced rectal cancer.

More Related