Top Research Priorities of STDWG

1. Top Research Priorities of STDWG • Impact of a RCT of HSV-2 suppression in prevention of HIV infection (Discretionary funds--039 and R01) • Association of male circumcision with risk for HIV infection and RCT to measure public health impact of circumcision for HIV prevention (Discretionary funds--R01) • Utility of a male microbicide for uncircumcised men to prevent HIV acquisition (041) • Comprehensive community-based STD interventions with core group, bridging and general population interventions. (Hybrid study) • Behavioral intervention for MSM with STDs as outcome (Behavioral and STDWGs)

2. STD Intervention Trials to Prevent HIV

3. STD Intervention Trials to Prevent HIV

4. Acquisition Probabilities per Act by HSV-2 Status of HIV-Negative Partner

5. HSV-2 and HIV: Relevance for HIV prevention • Is suppressive ACV for HIV prevention reasonable? • If effective, still a useful intervention when ART becomes more widely available • Increased probability of HIV acquisition among HSV2+ even at lowest HIV viral loads • ACV is cheaper, less infrastructure needed than HAART • Applicable to larger proportion of HIV+ (70-80% HSV2+ in Africa) than HAART based on CD4, and symptoms