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Mucosal immunity

Mucosal immunity. Epithelial barriers. Skin Mucosa. Skin 3 m 2 Mucosa 300 m 2 ↑ Ag pressure ( food , bacteria of GIT..) 80% imunoactive cells 90% infections 5-9 g IgA / day. Mucosal immunity. Tasks Infectious diseases defense Tolerance of innocent Ag.

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Mucosal immunity

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  1. Mucosalimmunity

  2. Epithelialbarriers SkinMucosa

  3. Skin 3 m2 Mucosa 300 m2 ↑ Agpressure (food,bacteriaofGIT..) 80% imunoactivecells 90% infections 5-9 g IgA /day

  4. Mucosalimmunity Tasks Infectiousdiseases defense Tolerance ofinnocentAg

  5. Moicroflora –host symbiosis • Colonizationrezistance • Epithelialcellsactivation • Immunesystemdevelopment • ?Whycomensalbacteria don´t induceinflammationunderphysiologicconditions

  6. Aguptake • DC • M cells. • Enterocytes • Macrophages

  7. Agpresentation Proffessional APC : DC, B cells, Macrophages InnocentAg– presented by immatureDC (↓CD80,86), IL-10, TGF-β, Th2, Th3 Oral tolerance Pathogen – presented by mature DC (↑ CD80,86), IL-12 Inflammation

  8. Recirculace

  9. Homing • α4β7 integrin (homing receptor) – MadCAM – 1(adresin)

  10. CommonmucosalimmunesystemSpolečný slizniční imunitní systém

  11. IgA transport

  12. IgApropertiesandfunction • Proteasesresistance • Neutralizationofvirusesandtoxins (alsoIC) • Microbs Adherence andinvasioninhibition • Opsonization • ADCC • Antiinflammatoryeffect

  13. Oral tolerance High doses of Ag - Anergy,deletion of autoreactive lymphocytes Low doses of Ag - Active supression, inhibitory cytokines production (TGF-β) Experimental models • RA • SM • DM

  14. Mucosal vaccines • Replicating Ag • Corpuscular Ag aimed to M cells – vectors (liposomes, micropatticles) • Epithelial cell binding proteins (cholera toxin)

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