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Unlocking the Potential of Stem Cells: A Journey of Regeneration

Explore the remarkable world of stem cells and their diverse potencies, from totipotent to unipotent, unlocking the secrets of regeneration in humans and beyond. Dive into the differences between embryonic and adult stem cells, uncover their unique characteristics, and ponder the question: can humans truly regenerate body parts? Discover the power within stem cells and the ongoing research to harness their capabilities for medical advancements and tissue regeneration.

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Unlocking the Potential of Stem Cells: A Journey of Regeneration

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  1. Stem Cells

  2. Remarkable Regeneration!

  3. Can humans regenerate body parts?

  4. Can humans regenerate body parts? Think – Pair – Share If humans have stem cells but can’t grow back certain body parts, but a lizard can grow back an entire tail, what must be different between our stem cells and a lizard’s?

  5. Stem Cells • Some stem cells are different than others! • Stem cells vary in what they can become. Some stem cells can only become one type of cell, other stem cells can generate an entire organism!

  6. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  7. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  8. Stem Cells • Potency • Totipotent: a stem cell that has the ability to divide and produce all the differentiated cells in an organism, including the placenta. A totipotent stem cell can generate an ENTIRE organism! • Example: cell from morula stage of embryo

  9. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  10. Stem Cells • Potency • Pluripotent: a stem cell that has the ability to divide and differentiate into any fetal or adult cell type (but not the placenta). Thus, a pluripotent stem cell can differentiate into any cell type but cannot become a new organism. • Example: cell from inner cell mass of blastocyst

  11. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  12. Stem Cells • Potency • Multipotent: a stem cell that has the ability to divide and differentiate into cells of a limited range of types. • Example: Blood stem cell (hematopoietic cell)

  13. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  14. Stem Cells • Potency • Unipotent: a stem cell that has the ability to divide and differentiate into only one type of cell. • Example: Skin stem cells

  15. Stem Cells • So, what IS a stem cell?

  16. Stem Cells Think – Pair – Share Think back to the definitions of potency we just discussed. What two characteristics do all stem cells have in common?

  17. Stem Cells • So, what IS a stem cell? • Two defining characteristics… • Self-renewal: Retain the capacity to go through many cycles of cell division while remaining undifferentiated. • Potency: Ability to differentiate

  18. Stem Cells • So, what IS a stem cell? • A stem cell is a cell that has the ability to self-renew and differentiate along different pathways.

  19. Embryonic stem cells vs. Adult Stem cells

  20. Embryonic stem cells vs. Adult Stem cells • Embryonic stem cell: stem cell derived from the inner cell mass of an embryo. • Are pluripotent

  21. Where do embryonic stem cells come from???

  22. Embryonic stem cells vs. Adult Stem cells • Adult stem cell: an undifferentiated cell taken from a tissue of the body that has the ability to divide and differentiate into specialized cell types.

  23. Where do adult stem cells come from? • Usually there is a very small number of stem cells in each tissue of body • Once removed, limited capacity to divide • Scientists trying to find better ways to grow large quantities of adult stem cells.

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