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Stem Cells

Stem Cells. Remarkable Regeneration!. Can humans regenerate body parts?. Can humans regenerate body parts?. Think – Pair – Share

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Stem Cells

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  1. Stem Cells

  2. Remarkable Regeneration!

  3. Can humans regenerate body parts?

  4. Can humans regenerate body parts? Think – Pair – Share If humans have stem cells but can’t grow back certain body parts, but a lizard can grow back an entire tail, what must be different between our stem cells and a lizard’s?

  5. Stem Cells • Some stem cells are different than others! • Stem cells vary in what they can become. Some stem cells can only become one type of cell, other stem cells can generate an entire organism!

  6. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  7. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  8. Stem Cells • Potency • Totipotent: a stem cell that has the ability to divide and produce all the differentiated cells in an organism, including the placenta. A totipotent stem cell can generate an ENTIRE organism! • Example: cell from morula stage of embryo

  9. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  10. Stem Cells • Potency • Pluripotent: a stem cell that has the ability to divide and differentiate into any fetal or adult cell type (but not the placenta). Thus, a pluripotent stem cell can differentiate into any cell type but cannot become a new organism. • Example: cell from inner cell mass of blastocyst

  11. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  12. Stem Cells • Potency • Multipotent: a stem cell that has the ability to divide and differentiate into cells of a limited range of types. • Example: Blood stem cell (hematopoietic cell)

  13. Stem Cells • Potency • Totipotent • Pluripotent • Multipotent • Unipotent

  14. Stem Cells • Potency • Unipotent: a stem cell that has the ability to divide and differentiate into only one type of cell. • Example: Skin stem cells

  15. Stem Cells • So, what IS a stem cell?

  16. Stem Cells Think – Pair – Share Think back to the definitions of potency we just discussed. What two characteristics do all stem cells have in common?

  17. Stem Cells • So, what IS a stem cell? • Two defining characteristics… • Self-renewal: Retain the capacity to go through many cycles of cell division while remaining undifferentiated. • Potency: Ability to differentiate

  18. Stem Cells • So, what IS a stem cell? • A stem cell is a cell that has the ability to self-renew and differentiate along different pathways.

  19. Embryonic stem cells vs. Adult Stem cells

  20. Embryonic stem cells vs. Adult Stem cells • Embryonic stem cell: stem cell derived from the inner cell mass of an embryo. • Are pluripotent

  21. Where do embryonic stem cells come from???

  22. Embryonic stem cells vs. Adult Stem cells • Adult stem cell: an undifferentiated cell taken from a tissue of the body that has the ability to divide and differentiate into specialized cell types.

  23. Where do adult stem cells come from? • Usually there is a very small number of stem cells in each tissue of body • Once removed, limited capacity to divide • Scientists trying to find better ways to grow large quantities of adult stem cells.

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