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Ampicillin & Infectious Mononucleosis

Ampicillin & Infectious Mononucleosis. Introduction. Associated with a high frequency of morbilliform rashes Maculopapular rashes are seen in 90% with EBV receiving ampicillin. Mechanism. Unknown ! Non-allergic reaction

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Ampicillin & Infectious Mononucleosis

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  1. Ampicillin & Infectious Mononucleosis

  2. Introduction • Associated with a high frequency of morbilliform rashes • Maculopapular rashes are seen in 90% with EBV receiving ampicillin.

  3. Mechanism • Unknown ! • Non-allergic reaction • Viral infections increased levels of IL5 upregulates expression of MHC class II antigens on keratinocytes. • Drug binds to MHC class II antigens and T cells can recognise the bound drug directly

  4. Management • Clear spontaneously

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