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Ampicillin in Infectious Mononucleosis: Risks and Management

Learn how ampicillin can cause morbilliform rashes in patients with infectious mononucleosis. Discover the unknown mechanism behind this reaction and how to manage it effectively. Spontaneous resolution is common.

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Ampicillin in Infectious Mononucleosis: Risks and Management

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  1. Ampicillin & Infectious Mononucleosis

  2. Introduction • Associated with a high frequency of morbilliform rashes • Maculopapular rashes are seen in 90% with EBV receiving ampicillin.

  3. Mechanism • Unknown ! • Non-allergic reaction • Viral infections increased levels of IL5 upregulates expression of MHC class II antigens on keratinocytes. • Drug binds to MHC class II antigens and T cells can recognise the bound drug directly

  4. Management • Clear spontaneously

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