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RTK family classification & structure/function

RTK family classification & structure/function. Implicated in diverse cellular responses: Regulate cell division Control differentiation—e.g., eye development in flies Regulate cell motility-remember PDGR in wounding At least 50 RTKs identified:

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RTK family classification & structure/function

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  1. RTK family classification & structure/function • Implicated in diverse cellular responses: • Regulate cell division • Control differentiation—e.g., eye development in flies • Regulate cell motility-remember PDGR in wounding • At least 50 RTKs identified: • Subdivided into 10 subclasses based on differences within extracellular, ligand-binding domain of receptor • Including many different types of domains • “Oncogenic” RTK mutants exist: • erbB gene encodes an N-terminal truncated, constitutively active form of EGF receptor while trk fusion protein with tropomyosin resulted in constitutive dimerization • Signal by ligand binding, receptor dimerization, “atuophosphorylation” and recruitment of proteins to cytoplasmic domain: • Many different SH2 domain proteins can bind to phosphorylated tyrosines including Grb2, Crk, Nck, PI-3-kinase, etc

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