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Ashraf S. Gorgey, MPT, PhD, FACSM; David R. Gater, MD, PhD

Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury. Ashraf S. Gorgey, MPT, PhD, FACSM; David R. Gater, MD, PhD. Aim

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Ashraf S. Gorgey, MPT, PhD, FACSM; David R. Gater, MD, PhD

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  1. Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury Ashraf S. Gorgey, MPT, PhD, FACSM; David R. Gater, MD, PhD

  2. Aim • Measure insulin-like growth factor-1 (IGF-1) in men with complete spinal cord injury (SCI) and spasticity. • Determine relationships between IGF-1 and thigh skeletal muscle cross-sectional areas (CSAs). • Relevance • We hypothesized that spasticity could defend against muscle atrophy and deleterious changes in body composition through its effects on IGF-1.

  3. Methods • 8 men with motor complete SCI underwent: • Magnetic resonance imaging to measure CSA of whole thigh, knee extensor, and knee flexor skeletal muscle groups. • Dual-emission X-ray absorptiometry to measure fat-free mass. • We then measured their: • IGF-1 levels. • Spasticity (using Modified Ashworth Scale [MAS]).

  4. Results • Plasma IGF-1 44% greater in those with MAS scores ≥2. • Plasma IGF-1 positively related to knee extensor skeletal muscle CSA. • IGF-1 strongly related to knee extensor and flexor spasticity. • Relationship between IGF-1 and: • Knee extensor spasticity. • Knee extensor skeletal muscle CSA.

  5. Conclusions • Findings suggest that IGF-1 is greater in SCI individuals with increased spasticity. • May explain strong positive relationships noted between spasticity and skeletal muscle CSA. • Maintaining muscle mass via spasticity or electrical stimulation resistance training may benefit body composition and insulin sensitivity and thereby improve health after SCI.

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