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Chem 250 Writing Assignment Lab 4 – Personal Care Product 10/10/14 one page summary of primary article due 10/24/14 annotated bibliography due 11/14/14 final project due. 0. Q: How do you detect chirality ? A: Polarimetry ! Chem Act 12A Model 3. 0.
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Chem 250 Writing AssignmentLab 4 – Personal Care Product 10/10/14 one page summary of primary article due 10/24/14 annotated bibliography due 11/14/14 final project due
0 Q: How do you detect chirality ? A: Polarimetry !Chem Act 12A Model 3
0 2 Stereogenic Centers and a plane of symmetry
0 Chemistry 250-02 Organic Chemistry I Fall, 2014 Day 13 10/1/14 Chapter 6 An Overview of Organic Reactions What Kind of Reactions Are There? Why do Reactions Happen? How do Reactions Happen? What Factors Control Reactions?
0 Functional Groups & Polarity
0 Functional Groups C-FG or R-FG
Reaction Mechanisms • Answer the question in detail: How do we get from reactants to products? • Include all steps in a multistep reaction • Indicate bond-making and bond-breaking by using curvedreaction arrows • Follow the electron flow so arrow becomes a new 2 electron bond ( - ) or a lone pair ( : ) Electrophile Nucleophile
How Are Bonds Broken and Made ? homolytic heterolytic Elec Nuc
Some Types of Organic Reactions • Addition • Elimination • Substitution hydrolysis - reaction with H2O condensation - formation of H2O • Rearrangement
Garoutte ChemAct 33 p. 133-134 Oxidation Reduction Substitution Hydrolysis Elimination (reverse is Addition) Acid-Base Oxidation - 3 types Add Oxygen Lose Hydrogen Loss of Electrons Substitution Condensation Addition (reverse is Elimination)
How do we classify these reactions?Addition, Elimination, Substitution, Rearrangement
How do we classify these reactions?Addition, Elimination, Substitution, Rearrangement Substitution Nucleophilic Polar-Ionic H+ Elimination Addition Δ Substitution Radical hν
What Kinds of Organic Reactions Are There ? How Can We Describe These Reactions ?Problem 6.1
What Kinds of Organic Reactions Are There ? How Can We Describe These Reactions ?Problem 6.1 elimination addition substitution rearrangement
Polar Reactions • Recall polarity • These reactions involve a nucleophile (e- - rich) and an electrophile (e- - poor) • What kind of reaction is this ?
What kind of reaction is the transformation shown below? • an elimination reaction • a rearrangement reaction • a substitution reaction • an addition reaction • none of these
In the reaction shown below which is the electrophile ? • propene • the H of HCl • the Cl of HCl • propane • none of these • all of these
In the reaction shown below which is the nucleophile ? • propene • the H of HCl • the Cl of HCl • propane • none of these • all of these
Which statement best describes the energetics of the reaction shown below?C2H4 + H2 → C2H6 • exothermic with positive activation energy • exothermic with negative activation energy • endothermic with positive activation energy • endothermic with negative activation energy • cannot be determined without knowing BDE’s
On the reaction energy profile shown below which species has the highest energy ? • I • II • III • IV • V
On the reaction energy profile shown below which is the highest energy intermediate? • I • II • III • IV • V
On the reaction energy profile shown below which represents the slowest step? • I to II • II to III • III to IV • IV to V • All steps proceed at the same rate
On the reaction energy profile shown below which represents the energy of the reaction? The energy difference between: • I and II • I and III • II and III • III and IV • III and V • I and V
Which of the following represents a correctly drawn reaction mechanism?
Where are the electrophilic sites?Where are the nucleophilic sites?
Two Reactions of Radicals R-H → R-H →
0 C-H bond breaking in alkanes