1 / 7

Emerging Data Regarding the Potential Benefits of Early Initiation of Clopidogrel Among ACS Patients

Emerging Data Regarding the Potential Benefits of Early Initiation of Clopidogrel Among ACS Patients. C. Michael Gibson, M.S., M.D. Inhibition of Platelet Aggregation Following Clopidogrel Administration. Hochholzer W et al. Circulation. 2005;111. Clopidogrel.

rich
Download Presentation

Emerging Data Regarding the Potential Benefits of Early Initiation of Clopidogrel Among ACS Patients

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Emerging Data Regarding the Potential Benefits of Early Initiation of Clopidogrel Among ACS Patients C. Michael Gibson, M.S., M.D.

  2. Inhibition of Platelet Aggregation Following Clopidogrel Administration Hochholzer W et al. Circulation. 2005;111

  3. Clopidogrel Clopidogrel Loading Dose Timing and Risk of MACE Log Odds of Death, MI or UTVR at 28 Days Placebo - 2 P = 0.020 for treatment / timing interaction - 3 - 4 - 5 - 6 0 5 10 15 20 25 30 Hours Prior to PCI of Study Drug Loading Dose J Am Coll Cardiol 2006;47:939–43.

  4. Influence of Thienopyridine Exposure – PCI pts 30 Day Primary Endpoint Adverse Events RR [95%CI] 0.81 (0.68-0.96) RR [95%CI] 0.96 (0.77-1.20) RR [95%CI] 0.50 (0.37-0.67) RR [95%CI] 1.07 (0.83-1.39) RR [95%CI] 1.37 (1.00-1.88) RR [95%CI] 0.61 (0.39-0.97) Thienopyridine Exposed Not Thienopyridine Exposed

  5. Clopidogrel stopped <5 days prior to CABG Clopidogrel stopped >5 days prior to CABG CURE: Major Bleeding in CABG Patients • Major or life-threatening bleeding w/in 7 days of CABG P=0.07 P=0.53 K.Fox et al, ESC 2002

  6. ACUITY: Primary Outcomes in CABG Patients • Patients with and without a thienopyridine administered in-hospital prior to CABG P=0.066 P=0.013 P=0.362 *Heparin=unfractionated or enoxaparin

  7. 30 Day Outcomes – CABG Patients by Thienopyridine Status • Patients with and without a thienopyridine administered in-hospital prior to CABG

More Related