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Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery

Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences?. Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery University of Ilorin Teaching Hospital ,Ilorin. Introduction.

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Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery

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  1. Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences? AdemolaPopoola ,BUHARI TAJUDEEN ,FidelisUshie ,HamidOlanipekun. Department of Surgery University of Ilorin Teaching Hospital ,Ilorin.

  2. Introduction • Prostate cancer is the most commonly diagnosed malignancy affecting men beyond middle age. • Is the most common non cutaneous malignancy in the Western world. • 2nd leading cause of cancer death in men. • It is a major public health burden in Sub Sahara Africa. • In practice, prostate cancer has been reported to occur simultaneously (synchronous) or successively (metachronous).

  3. Introduction [Cont’d] • Some multiple cancer syndromes have been well defined. These include Von HippelLindau Syndrome (cerebellar & retinal heamangioma, renal, pancreatic and spinal meningeal tumors).

  4. Aim • To report Multiple Primary Cancers (MPC) involving Prostate cancer in our centre in the last two years. • To identify from the literature possible associations of simultaneously occurring cancers.

  5. Methodology • Retrospective analyses from our database of patients with MPC involving prostate cancer in the last two years. • Review of existing literature for possible association.

  6. Discussion

  7. Discussion [Cont’d] • Prostate cancer could occur with other primary tumours as synchronous or metachronous. • This has been adduced to increased life span and improved diagnostic tools. • There are existing literatures reporting prostate cancer occurring with all the other primary tumors in our series. • Lee et al; reported 4.03% finding of prostate cancer in radical cystoprostatectomy specimen (Asian J. Andrology, 2006).

  8. Discussion [Cont’d] • The incidence of other primary tumours in the setting of primary liver cell carcinoma is relatively common with a strong clustering of genitourinary and gastro-intestinal malignancies. • Synchronous thyroid tumours have been reported following radiation for head and neck tumours. In our report, it was discovered after External beam radiation therapy to the pelvis. • Prostate cancer with Rectal cancer - Post Radiotherapy - Age

  9. Discussion [Cont’d] • Prostate cancer with Colonic tumours - Genetics: (i) mutation of BRCA2 gene (ii) mutation of MMR gene (Lynch syndrome)

  10. Challenges • To make Diagnosis. • Diagnostic tools are limited: availability and affordability. • Between oncologic cure and preservation of functional anatomy/quality of life. • No established guideline. • Poor cancer registry. • Low rate of postmortem and radical procedures.

  11. Conclusion • MPC occurrence are probably more than the documented cases. • Detailed clinical evaluation is key. • There is need for more multidisciplinary approach to care. • There is also need for genetics study.

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