E N D
1. ?16? ?????? Antihistamines
2. Histamine? ????
???, ??, ??? ?? ??? ??
?????? ?? ????
???, ?? ???? ??, ????
3. Antihistamine Antagonists H1 antagonist : ???? ??? ??, ?,?,?? ???? ? allergy ??? ??. ???? ????, ???, ??? ?
H2 antagonist : ????? ????? ??? ?? ? ???? ??. ???? ??, ???, ???, ???? ?
4. ??????? ?? ??
6. ??-????(H1 antagonist) Aminoalkyl ether(X:O)
Ethylenediamine(X:N)
Alkylamine(X:CH)
Piperazine
Phenothiazine
?? ???
????? ??? ?????? ??????? ??? ?? ??? ?? ???? ??.? potentiates the depressant activity of barbiturate, alcohol, narcotic analgesics and other depressants 1. R,R’? methyl?? ?? ??? ??.
2. ??? 3? ???? ??, ??? pH?? protonation
3.??? ?? imidazole? ??? ??
4. X? N??? ??? ??? 2 ?? 3?? ????? 5??6 angstrom??? ??? ??
8. Ethanolamine? ??? ??????
9. Ethylenediamine? ??????? ???? ? ????
10. Piperazine? ?????? ???? ? ????
23. H2 antagonist
25. Cimetidine? ??
27. H2 antagonist
32. ??? ?? ??? (proton pump inhibitor)