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Medical and Health Science Center

University of Debrecen. 450 years; the oldest institution of higher education of continuous history in Hungary. Number of students: 29 121 Academic staff (full time): 1 413 Non-academic staff (full time): 5 312 Annual budget (2007): ~68,6 billion HUF ( 275 million € ).

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Medical and Health Science Center

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  1. University of Debrecen • 450 years; the oldest institution of higher education of continuous history in Hungary • Number of students:29 121 • Academic staff (full time): 1 413 • Non-academic staff (full time): 5 312 • Annual budget (2007): ~68,6 billion HUF (275 million €) 15 faculties in three centers Centre of Arts, Humanities and Sciences Medical and Health Science Center Centre for Agricultural Sciences and Engineering • Medicine • Dentistry • Pharmacy • Public Health • Health Sciences • Science andTechnology • Humanities • Informatics • Economics • Law • Music • Education • Agriculture • Engineering • Rural Development

  2. Molecular Medicine Molecular Cell and Immune Biology Clinical Medicine Clinical Medicine Health Sciences Dentistry Pharmacology and Pharmaceutical Sciences Mathematics and computing Informatics Physics Chemistry Earth Sciences Biology and Environmental Sciences Graduate and PhD schools • History and Ethnology • Literature • Linguistics • Humanities (Philosophy, Psychology and Education) • Law • Economics • Management and Business Administration • Crop Production, Horticulture and Food Sciences • Crop Production, Horticulture and Regional Sciences • Animal Husbandry

  3. Based on its research activity UD ranks among the top three universities in Hungary (Ministry of Education); 70% of the academic staff hold PhD degree; 26 members of the Hungarian Academy of Sciences (10 new ones since the year 2000); 11 research groups sponsored by special grant of the Hungarian Academy of Sciences; 23 Ph.D. schools (highest number in Hungary); Close to 800 PhD students; 150-200 new PhD degrees issued per annum; R&D income ~4,5 billion HUF/year (~18 million €). University of Debrecen: The researchuniversity

  4. Research Centre for Molecular Medicine

  5. University of Debrecen, Medical and Health Science Center

  6. RCMM - introduction 1. Research Centre for Molecular Medicine Medical and Health Science Center University of Debrecen Centre of Excellence of the European Union (2002)

  7. RCMM - introduction 2. • Research institute • Clinically oriented and basic cutting edge research • Collaborating research laboratories • Core facilities • International partner institutions

  8. RCMM - Basic Research 1. • Molecular Mechanism of Apoptosis • Apoptosis Signaling • Nuclear Hormone Receptor • Retroviral Biochemistry • Dendritic Cell Research

  9. RCMM - Basic Research 2. • Cell Biophysics • Lymphocyte Electrophysiology • Receptor Tyrosine Kinases • Cell Biology • Membrane Dynamics

  10. RCMM - Basic research 3. • Signal Transfer • Oxidative Stress and ADP-ribosylation • Protein Phosphatases in Cellular Signaling • Protein Dephosphorylation

  11. RCMM - Basic Research 4. • Cellular and Molecular Physiology • Calcium Homeostasis and Transmembrane Signaling • K+ Channels in Excitable and Non-excitable Structures

  12. RCMM - Clinical Research • Haemostasis Thrombosis and Vascular Biology Research • Vascular Biology Research • Earpathology • Genetics of Corneal and Retinal Dystrophies and Degenerations • Cardiology, Clinical Physiology

  13. RCMM - Core Facilities • Debrecen Clinical Genomics Centre • High-throughput Screening (HTS) Facility • Cell Analysis Core Facility • Lipidomics Core Facility • Laboratory Animal Core Facility • Biomolecular Interaction Laboratory • Proteomics Core Facility

  14. Debrecen Award for Molecular Medicine • International annual price of 10 000 EUR • Aim: encouraging, recognizing and promoting extraordinary research results • Winner in 2008: Bruce M. Spiegelman

  15. http://rcmm.dote.hu Please visit our web site.

  16. MOLMEDREX project Coordination and Support Action FP7-REGPOT-2008-1/229920

  17. RCMM • Research Centre for Molecular Medicine • Basic and cutting edge biomedical research • Research Groups + Core Facilities • Centre of Excellence

  18. MOLMEDREX - aims • Human potential • Research equipment • Mobility of researchers • Dissemination of results

  19. Selected Research Fields Genomics/Gene expression- Personalized medicine Advanced Imaging High throughput screening in an academic setting

  20. MOLMEDREX - Work Packages • WP1 Development of the research potential in strategic areas by twinning and partnerships • WP2 Increasing human potential of RCMM • WP3 Upgrading infrastructure • WP4 Establishing RCMM as a regional knowledge centre • WP5 Dissemination • WP6 Project management

  21. MOLMEDREX - WP1 • Twinning & Partnership • Twinning Partners: DKFZ, EMBL • Strategic Partners: 14 leading universities • Aim: expanding RTD capacity, gaining further expertise and new technologies in genomics, imaging and HTS • Collaborations: secondments, lab meetings, visits, lectures seminars

  22. MOLMEDREX- WP2 • Increasing human potential of RCMM • Aim: reinforcing S & T competitiveness, upgrading RTD capability in new, highly competent research fields (personalized medicine, stem cell research, molecular imaging etc.) • 4 senior and 4 junior researcher positions are offered in different fields

  23. MOLMEDREX - WP3 • Upgrading infrastructure • Aims: broadening the scope of methods, improving efficiency • Equipment purchased is unique in the region and nationwide (Microarray platform, Semi-automatized Patch Clamp robot, Andor camera, Microplate dispenser, centrifuge, UV irradiator, TIRF PALM Microscope purchase in progress)

  24. MOLMEDREX - WP4 • Establishing RCMM as a regional knowledge centre in the field of biomedical research • Training courses, conferences, workshops will be organized • E.g. GeneSpring course, Practical Course on Techniques in Free Radical Biology (http://febs.unideb.hu) • Co-funding by EMBO or FEBS

  25. MOLMEDREX - WP5 • Dissemination of results • Aims: dissemination, marketing, promotion of results • E-platform, newsletters, brochures, publications, presentation at international conferences, Alumni program, Annual report etc. • Target groups: regional, national, EU, global research facilities in academia and industry (Biotech, Pharma), policy-makers, politicians, legislative bodies, selected patient groups, multiple sectors of the lay public

  26. MOLMEDREX - WP6 • Aims: administration, coordination and motivation of all the activities in the project • Advisory group (senior scientists of UD, local biotech, local government, national R&D agency)

  27. Expected results of MOLMEDREX project As a result RCMM will become a more potent and prepared research centre in the Eastern part of Hungary with an improved human and infrastructural capacity to tackle key issues in molecular medicine for the benefit of the population of the region.

  28. http://molmedrex.dote.hu Please visit our web site!

  29. Thank you for your attention!

  30. Debrecen Clinical Genomics Centerhttp://genomics.dote.hu

  31. Services • Study design, consulting • Patient recruitment • Biobanking • Integrated database • Functional analysis: Functional genomic analysis services and epigenomic analysis services • Data analysis / mining

  32. Infrastructure • Affymetrix GeneChip 3000 7G System, • 2 pc ABI 7900 Real-time quantitative PCR instruments, • ABI 310 Avant DNA sequencer, • 2 pc Light Cycler 480 (Roche) • MMI UV cut laser microdissector, • Tecan Genesis RSP150 • Tecan Miniprep 75 • MagnaPure LC • FaCScalibur • Agilent Bioanalyzer 2100 • 2 pc NanoDrop 1000

  33. Methods • Microarray technology • Real-time quantitative PCR including Minimal residual disease (MRD) analysis, miRNA detection, Genotyping qPCR Assay (SNP detection), TaqMan Low Density Array (Microfluidics Card) • Sanger DNA sequencing; • Nucleic acid isolation; • Molecular cloning • Chromatin immunoprecipitation (ChIP) • Methylated DNA Immunoprecipitation (MeDIP)

  34. References • Debrecen Clinical Genomics Center 2001 – 2007 • 2005-2007 Biosystems International SAS, • 2006-2007 Richter Gedeon Nyrt., • 2006-2007 AstraZeneca • 2001-2007 Pfizer Global Research • UD-GenoMed Ltd. 2008 –

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