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Resveratrolo

Resveratrolo. Antiestrogens can stop harmful effects of estrogen. Ligand Induces a Conformational Change in the LBD that Repositions helix 12. No Ligand. Agonist. NR Antagonists Alter the Position of Helix 12. Agonist (ER). Antagonist (ER). No Ligand. SERMs.

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Resveratrolo

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  1. Resveratrolo

  2. Antiestrogens can stop harmful effects of estrogen

  3. Ligand Induces a Conformational Change in the LBD that Repositions helix 12 No Ligand Agonist

  4. NR Antagonists Alter the Position of Helix 12 Agonist (ER) Antagonist (ER) No Ligand

  5. SERMs (Selective Estrogen Receptor Modulators)

  6. OH PHENOL • >100,000 Compounds • classified according to basic skeletal structure • acidic • Participates in oxidation-reduction reactions

  7. Polyphenol content

  8. Vascular benefitsQuercetin, catechin, resveratrol • Inhibition of platelet aggregation • Inhibition of LDL oxidation (plaque) • Vasodilation • Inhibition of vasoconstriction (tannins)

  9. Anti-carcinogenic properties • Stilbenes inhibit cell proliferation • Association with decreased colon cancer • Inhibition of non-melanoma skin cancer -resveratrol • Estrogenic effect-resveratrol +/-

  10. Resveratrolo

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