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Polymorphism of Organic Materials Lian Yu, University of Wisconsin - Madison, DMR 0804786

Polymorphism of Organic Materials Lian Yu, University of Wisconsin - Madison, DMR 0804786.

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Polymorphism of Organic Materials Lian Yu, University of Wisconsin - Madison, DMR 0804786

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  1. Polymorphism of Organic MaterialsLian Yu, University of Wisconsin - Madison, DMR 0804786 Schmelzer’s model attributes fast surface crystal growth to easy release of crystallization-induced tension, and for different polymorphs, predicts that the growth of denser polymorph be more enhanced by the surface. But this is not observed As organic liquids are cooled to become glasses, crystal growth at the free surface can be substantially faster than in the interior, a phenomenon uncommon for other materials and for which different explanations exist. We have measured the surface and bulk growth rates of three polymorphs in carbamazepine glasses. Crystal density has no controlling effect on the extent to which surface crystal growth is enhanced over bulk crystal growth, in contradiction to models that relate fast surface crystal growth to the release of crystallization-induced tension. Model predicts positive slope Gunn et al. Cryst. Growth Des.2011, 11, 3979

  2. GOALI: Crystallization of Organic GlassesLian Yu, University of Wisconsin - Madison, DMR 0804786 Our group played a key part in the UW PEOPLE program designed to broaden the education of high-school students from underrepresented groups. This year’s class was on polymers. The 15 students learned about chemical bonds, polymer structures, the effect of crosslinking on physical properties, and the use of polymers in nanolithography. The results from our research were part of the course materials which Yu used in his graduate course Molecular Solids, and an X-ray diffraction workshop at NYU. Our work has had strong impact in the pharmaceutical science community. Yu has organized conferences and given lectures on amorphous drugs. AAPS recognized the success of this project in conferring to the laboratory one of its highest awards – David Grant Award in Physical Pharmacy. Dr. Danielle Musumeci explains materials chemistry to high-school students in the UW PEOPLE program Collaborations: We developed collaborations with R. Richert (Arizona St. U.), R. Davey (U. Manchester), M. Ediger (UW-Madison), and G. Zhang (Abbott). Dissemination of research results: The students and PI presented the results in scientific meetings, universities, and companies.

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